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You are here: Home Research Scientific Computing Publications A second order algorithm for solving dynamic cell membrane equations

J. Sundnes, R. Artebrant, O. Skavhaug, and A. Tveito (2009)

A second order algorithm for solving dynamic cell membrane equations

IEEE Transactions on Biomedical Engineering 56(10):2546-2548

This paper describes an extension of the so-called Rush-Larsen scheme, which is a widely used numerical method for solving dynamic models of cardiac cell electrophysiology. The proposed method applies a local linearization of non-linear terms in combination with the analytical solution of linear ordinary differential equations, to obtain a second order accurate numerical scheme. We compare the error and computational load of the second order scheme to the original Rush-Larsen method. For a given error tolerance, the second order method is from nine to 500 times faster than the original scheme, depending on the choice of model and tolerance.
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