Kimberly McCabe

M. T. Hock, A. Teitgen, K. J. McCabe, S. P. Hirakis, G. Huber, M. Regnier, R. E. Amaro, A. J. McCammon and A. D. McCulloch

Multiscale computational modeling of the effects of 2’-deoxy-ATP on cardiac muscle calcium handling

Journal of Applied Physics

K. Ngo, N. T. Herrera, M. Folkmanaite, K. Yamamoto and M. M. Maleckar

In silico Investigation of Sex-Specific Osteoarthritis in Human Articular Chondrocytes

J. Cui, M. R. Domingo, R. Konno, C. A. Manetti, G. Kagugube, O. O. Odeigah and J. Sundnes

Impact of Pathological Vascular Remodelling on Right Ventricular Mechanics

Computational Physiology: Simula Summer School 2022- Student Reports

A. Contri, C. Taylor, J. Tso and I. Gjerde

Inducing Flow Instabilities in Aneurysm Geometries via the Reynolds-Orr Method

Computational Physiology Simula Summer School 2022 − Student Reports

M. H. Mesa, J. van den Brink, W. E. Louch, K. J. McCabe and P. Rangamani

Nanoscale organization of ryanodine receptor distribution and phosphorylation pattern determines the dynamics of calcium sparks

PLOS Computational Biology

J. J. Uv, L. Myklebust, H. K. Rudsari, H. Welle and H. Arevalo

3D Simulations of Fetal and Maternal Ventricular Excitation for Investigating the Abdominal ECG

Computational Physiology - Simula Summer School 2021 - Student Reports

N. Berre, G. Castro, H. Kjeldsberg, R. Masri and I. Gjerde

A Computational Study of Flow Instabilities in Aneurysms

Computational Physiology - Simula Summer School 2021 - Student Reports

K. G. Hustad, E. Ivanovic, A. L. Recha and A. A. Sakthivel

Conduction Velocity in Cardiac Tissue as Function of Ion Channel Conductance and Distribution

Computational Physiology - Simula Summer School 2021 − Student Reports

B. Singstad, B. S. Dalen, S. Sihra, N. Forsch and S. Wall

Identifying Ionic Channel Block in a Virtual Cardiomyocyte Population Using Machine Learning Classifiers

Computational Physiology - Simula Summer School 2021 - Student Reports

K. Yamamoto, S. Fischer-Holzhausen, M. P. Fjelstad and M. Maleckar

Ordinary Differential Equation-based Modeling of Cells in Human Cartilage

Computational Physiology - Simula Summer School 2021 - Student Reports

K. J. McCabe

Computational Physiology: Simula Summer School 2021 − Student Reports

Simula SpringerBriefs on Computing

K. J. McCabe and P. Rangamani

Computational modeling approaches to cAMP/PKA signaling in cardiomyocytes

Journal of Molecular and Cellular Cardiology

K. J. McCabe, Y. Aboelkassem, A. Teitgen, G. Huber, A. J. McCammon, M. Regnier and A. D. McCulloch

Predicting the effects of dATP on cardiac contraction using multiscale modeling of the sarcomere

Archives of Biochemistry and Biophysics

K. J. McCabe, Y. Aboelkassem, A. Teitgen, M. Regnier and A. D. McCulloch

Multiscale modelling determines mechanisms of action for 2'-deoxy-ATP, a myosin activating therapeutic for heart failure

VPH 2020, Paris, France (Virtual)

Y. Aboelkassem, K. J. McCabe, G. Huber, M. Regnier, A. J. McCammon and A. D. McCulloch

A Stochastic Multiscale Model of Cardiac Thin Filament Activation Using Brownian-Langevin Dynamics

Biophysical Journal

J. D. Powers, C. Yuan, K. J. McCabe, J. D. Murray, M. C. Childers, G. Flint, F. Moussavi-Harami, S. Mohran, R. Castillo, C. Zuzek, W. Ma, V. Daggett, A. D. McCulloch, T. C. Irving and M. Regnier

Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin

Proceedings of the National Academy of Sciences

Y. Aboelkassem, J. D. Powers, K. J. McCabe and A. D. McCulloch

Multiscale Models of Cardiac Muscle Biophysics and Tissue Remodeling in Hypertrophic Cardiomyopathies

Current Opinion in Biomedical Engineering

K. J. McCabe, Y. Aboelkassem, S. Dewan, M. Regnier and A. D. McCulloch

A Markov State Model of the Sarcomere to Explain the Effects of dATP on Cardiac Contraction

Y. Aboelkassem, K. J. McCabe, G. Huber, J. Sundnes and A. D. McCulloch

Turning the Azimuthal Motions of Adjacent Tropomyosins into a Coupled N-body Problem in a Brownian Model of Cardiac Thin Filament Activation

Biophysical Journal

S. Dewan, K. J. McCabe, M. Regnier and A. D. McCulloch

Insights and Challenges of Multi-Scale Modeling of Sarcomere Mechanics in cTn and Tm DCM Mutants—Genotype to Cellular Phenotype

Frontiers in Physiology

S. Dewan, K. J. McCabe, M. Regnier, A. D. McCulloch and S. Lindert

Molecular Effects of cTnC DCM Mutations on Calcium Sensitivity and Myofilament Activation—An Integrated Multiscale Modeling Study

The Journal of Physical Chemistry B

Y. Aboelkassem, J. Bonilla, K. J. McCabe and S. Campbell

Contributions of Ca 2+ -Independent Thin Filament Activation to Cardiac Muscle Function

Biophysical Journal