Dissipation caused by the aqueduct in healthy and diseases cases (dementia, Alzheimer)

The CSF circulation of the ventricular system appears to be involved in many different diseases, but is inadequately described and understood. It is known that there are concentration gradients between the different ventricles of crucial solutes such as melatonin, vitamin C, etc.
Master

We hypothesize that these gradients are important for healthy metabolism. Conditions that disturb the CSF circulation likely disturb the natural concentration gradients between the various compartments associated with the brain. For example, adult hydrocephalus is a well-known form of dementia in which the CSF circulation is hyper-kinetic. The hyper-kinetic flow may lead to increased dissipation and reduced concentration gradients. It is well known that these forms of dementia are associated with sleeping disorders. Our recent research has established the importance of breathing patterns for this circulation and hereby providing links to for instance yoga and meditation.

At the University hospital of Oslo, a unique technique offers the possibility of quantification of the dissipative effects of the hyperkinetic CSF flow. The topic of this project is to develop CFD code and conduct numerical experiments that determine the dissipation in a patient-specific manner.

Learning outcome

Finite element methods, fluid dynamics, analysis of medical images.

Qualifications

A background in mechanics or partial differential equations and programming, e.g., INF5620, INF3331, MEK2200, MAT3360 

Supervisors

Kent-André Mardal

Per Kristian Eide (Rikshospitalet)

Geir Ringstad (Rikshospitalet)

 

External announcement