Modeling acute hydrocephalus following stroke
Hydrocephalus (Norwegian: vannhode) is a condition where the ventricles (cavities filled with cerebrospinal fluid (CSF) - essentially water) within the brain become enlarged. It is well known that acute hydrocephalus often (around 50-90%) follows stroke cause by bleeding and in fact the development of hydrocephalus may be as deadly as the original stroke. The cause is currently unknown, but the development is clearly seen as massive compression of brain tissue occuring over the timescale of hours to days. In this project we will investigate to what extent a specific hypothesis for hydrocephalus development is plausible. The surface of the brain is covered by a membrane called the pia mater and is bathed in CSF. Bleedings are usually caused by rupture of aneurysms located at major arteries (aneurysms associated with the circle of Willis) and the bleeding is therefore mainly into the CSF at there surface of the brain where it is spreads before the blood accumulates at the pia mater. As the blood accumulates at the pia mater it changes permeability and elastic parameters, hypothetically causing in-balance in the fluid transfer and pressure propagation between the CSF, pia mater and brain. In this project we will investigate the plausibility of this hypothesis in terms of poro-elastic modeling of patient-specific cases of hydrocephalus.
Finite element methods, solid mechanics, analysis of medical images.
A background in mechanics or partial differential equations and programming, e.g., INF5620, INF3331, MEK2200, MAT3360
Per Kristian Eide