Andy Edwards

X. Zhang, H. Ni, S. Morotti, C. E. R. Smith, D. Sato, W. E. Louch, A. G. Edwards and E. Grandi

Mechanisms of spontaneous Ca ²⁺ release‐mediated arrhythmia in a novel 3D human atrial myocyte model: I. Transverse‐axial tubule variation

The Journal of Physiology

X. Zhang, C. E. R. Smith, S. Morotti, A. G. Edwards, D. Sato, W. E. Louch, H. Ni and E. Grandi

Mechanisms of spontaneous Ca²⁺ release‐mediated arrhythmia in a novel 3D human atrial myocyte model: II Ca²⁺‐handling protein variation

The Journal of Physiology

V. Charwat, B. Charrez, B. A. Siemons, H. Finsberg, K. H. Jæger, A. G. Edwards, N. Huebsch, S. Wall, E. Miller, A. Tveito and K. E. Healy

Validating the Arrhythmogenic Potential of High-, Intermediate-, and Low-Risk Drugs in a Human-Induced Pluripotent Stem Cell-Derived Cardiac Microphysiological System

ACS Pharmacology & Translational Science

K. H. Jæger, A. G. Edwards, W. R. Giles and A. Tveito

Arrhythmogenic influence of mutations in a myocyte‑based computational model of the pulmonary vein sleeve

Nature Scientific Reports

X. Shen, J. van den Brink, A. Bergan-Dahl, T. R. Kolstad, E. S. Norden, Y. Hou, M. Laasmaa, Y. Aguilar-Sanchez, A. P. Quick, E. K. S. Espe, I. Sjaastad, X. H. Wehrens, A. G. Edwards, C. Soeller and W. E. Louch

Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes

eLife

N. Huebsch, B. Charrez, G. Neiman, B. Siemons, S. C. Boggess, S. Wall, V. Charwat, K. H. Jæger, D. Cleres, Å. Telle, F. T. Lee-Montiel, N. C. Jeffreys, N. Deveshwar, A. G. Edwards, J. Serrano, M. Snuderl, A. Stahl, A. Tveito, E. W. Miller and K. E. Healy

Metabolically driven maturation of human-induced-pluripotent-stem-cell-derived cardiac microtissues on microfluidic chips

Nature Biomedical Engineering

W. E. Louch, H. Perdreau-Dahl and A. G. Edwards

Image-Driven Modeling of Nanoscopic Cardiac Function: Where Have We Come From, and Where Are We Going?

Frontiers in Physiology

A. G. Edwards, J. van den Brink and A. D. McCulloch

Calcium Signaling in Cardiomyocyte Models With Realistic Geometries

Zipes and Jalife's Cardiac Electrophysiology: From Cell to Bedside

K. H. Jæger, A. G. Edwards, W. R. Giles and A. Tveito

A computational method for identifying an optimal combination of existing drugs to repair the action potentials of SQT1 ventricular myocytes

PLoS Computational Biology

B. Charrez, V. Charwat, B. Siemons, H. Finsberg, E. Miller, A. G. Edwards and K. E. Healy

In vitro safety “clinical trial” of the cardiac liability of drug polytherapy

Clinical and Translational Science

B. Charrez, V. Charwat, B. Siemons, I. Goswami, C. Sakolish, Y. Luo, H. Finsberg, A. G. Edwards, E. Miller, I. Rusyn and K. Healy

Heart Muscle Microphysiological System for Cardiac Liability Prediction of Repurposed COVID-19 Therapeutics

Frontiers in Pharmacology

K. H. Jæger, A. G. Edwards, W. R. Giles and A. Tveito

From Millimeters to Micrometers; Re-introducing Myocytes in Models of Cardiac Electrophysiology

Frontiers in Physiology

A. G. Edwards, H. Mørk, M. K. Stokke, D. B. Lipsett, I. Sjaastad, S. Richard, O. M. Sejersted and W. E. Louch

Sarcoplasmic Reticulum Calcium Release Is Required for Arrhythmogenesis in the MouseData_Sheet_1.pdf

Frontiers in Physiology

A. F. Iseppe, H. Ni, S. Zhu, X. Zhang, R. Coppini, P. Yang, U. Srivatsa, C. E. Clancy, A. G. Edwards, S. Morotti and E. Grandi

Sex‐Specific Classification of Drug‐Induced Torsade de Pointes Susceptibility Using Cardiac Simulations and Machine Learning

Clinical Pharmacology & Therapeutics

V. Timmermann, A. T. Quinn, J. Sundnes, S. Wall, A. D. McCulloch and A. G. Edwards

A computational study on integrated mechanisms of mechano-electric feedback in ischemic arrhythmogenesis

SAGE

T. Mäki-Marttunen, N. Iannella, A. G. Edwards, G. T. Einevoll and K. T. Blackwell

A unified computational model for cortical post-synaptic plasticity

eLife

B. Charrez, V. Charwat, B. Siemons, H. Finsberg, E. Miller, A. G. Edwards and K. E. Healy

In Vitro Safety “Clinical Trial” of the Cardiac Liability of Hydroxychloroquine and Azithromycin as COVID19 Polytherapy

Clinical Pharmacology & Therapeutics

X. Shen, T. R. Kolstad, J. van den Brink, M. Frisk, Y. Hou, E. Norden, A. G. Edwards, I. Sjaastad, C. Soeller and W. E. Louch

3D Dstorm Imaging Reveals Camkii-Dependent Dispersal of Ryanodine Receptor Clusters in Failing Rat Cardiomyocytes

Biophysical Journal

X. Shen, J. van den Brink, Y. Hou, D. Colli, C. Le, T. R. Kolstad, N. MacQuaide, C. R. Carlson, P. M. Kekenes-Huskey, A. G. Edwards, C. Soeller and W. E. Louch

3D dSTORM imaging reveals novel detail of ryanodine receptor localization in rat cardiac myocytes

The Journal of Physiology

K. H. Jæger, A. G. Edwards, A. D. McCulloch and A. Tveito

Properties of cardiac conduction in a cell-based computational model

PLoS Computational Biology

T. Mäki-Marttunen, T. Kaufmann, T. Elvs\aashagen, A. Devor, S. Djurovic, L. T. Westlye, M. Linne, M. Rietschel, D. Schubert, S. Borgwardt, M. Efrim-Budisteanu, F. Bettella, G. Halnes, E. Hagen, S. Næss, T. Ness, T. Moberget, C. Metzner, A. G. Edwards, M. Fyhn, A. M. Dale, G. T. Einevoll and O. A. Andreassen

Biophysical Psychiatry—How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders

Frontiers in psychiatry

V. Timmermann, A. G. Edwards, S. Wall, J. Sundnes and A. D. McCulloch

Arrhythmogenic current generation by myofilament-triggered Ca2+ release and sarcomere heterogeneity

Biophysical Journal

V. Timmermann, J. Sundnes, S. Wall, A. D. McCulloch and A. G. Edwards

A one-dimensional computational study of mechano-electric feedback and arrhythmogenic current generation

Gordon Research Conference "Cardiac Arrhythmia Mechanisms", Barga, Italy

M. Vagos, I. G. M. van Herck, J. Sundnes, H. Arevalo, A. G. Edwards and J. Koivumäki

Computational Modeling of Electrophysiology and Pharmacotherapy of Atrial Fibrillation: Recent Advances and Future Challenges

Frontiers in Physiology

A. Tveito, K. H. Jæger, N. Huebsch, B. Charrez, A. G. Edwards, S. Wall and K. E. Healy

Inversion and computational maturation of drug response using human stem cell derived cardiomyocytes in microphysiological systems

Nature Scientific Reports

T. R. Kolstad, J. van den Brink, N. MacQuaide, P. K. Lunde, M. Frisk, J. M. Aronsen, E. S. Norden, A. Cataliotti, I. Sjaastad, O. M. Sejersted, A. G. Edwards, G. T. Lines and W. E. Louch

Ryanodine Receptor Dispersion Disrupts Ca2+-Release in Failing Cardiac Myocytes

eLife

N. Huebsch, B. Charrez, B. Siemons, S. C. Boggess, S. Wall, V. Charwat, K. Jaeger, F. L. T. Montiel, N. C. Jeffreys, N. Deveshwar, A. G. Edwards, J. Serrano, M. Snuderl, A. Stahl, A. Tveito, E. W. Miller and K. E. Healy

Metabolically-Driven Maturation of hiPSC-Cell Derived Heart-on-a-Chip

{bioRxiv

T. Mäki-Marttunen, F. Krull, F. Bettella, E. Hagen, S. Næss, T. Ness, T. Moberget, T. Elvs\aashagen, C. Metzner, A. Devor, A. G. Edwards, M. Fyhn, S. Djurovic, A. M. Dale, O. A. Andreassen and G. T. Einevoll

Alterations in Schizophrenia-Associated Genes Can Lead to Increased Power in Delta Oscillations

Cerebral Cortex

I. van Herck, B. H. Bentzen, V. Seutin, H. Arevalo, M. Maleckar, N. Marrion and A. G. Edwards

Model development of sk channel gating incorporating calcium sensitivity and drug interaction

Biophysical Journal

I. G. M. van Herck, B. H. Bentzen, V. Seutin, J. Koivumäki, M. Maleckar, N. Marrion and A. G. Edwards

In silico Model of Gating Kinetics, Temperature Dependence and Calcium Sensitivity of the SK Channel

I. G. M. van Herck, B. H. Bentzen, V. Seutin, H. Arevalo, M. Maleckar, N. Marrion and A. G. Edwards

Model development of SK channel gating incorporating calcium sensitivity and drug interaction

S. Wall, A. Tveito, K. H. Jæger, A. G. Edwards, K. Healy, N. Huebsch and B. Charrez

In Silico Modeling of Cardiac Microphysiological Systems for Evaluating Drug Side Effects

Heart By Numbers Conference, Berlin, Germany

V. Timmermann, J. Sundnes, S. Wall, A. D. McCulloch and A. G. Edwards

A computational study of the contribution of mechano-electric feedback to arrhythmogenic current generation

Berlin, Germany

M. Maleckar, A. G. Edwards, W. Louch and G. T. Lines

Studying dyadic structure-function relationships: a review of current modeling approaches and new insights into Ca2+ (mis)handling

Clinical Medicine Insights: Cardiology

A. Tveito, K. H. Jæger, G. T. Lines, Ł. Paszkowski, J. Sundnes, A. G. Edwards, T. Mäki-Marttunen, G. Halnes and G. T. Einevoll

An Evaluation of the Accuracy of Classical Models for Computing the Membrane Potential and Extracellular Potential for Neurons

Frontiers in Computational Neuroscience

T. Mäki-Marttunen, G. T. Lines, A. G. Edwards, A. Tveito, A. M. Dale, G. T. Einevoll and O. A. Andreassen

Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling

Translational Psychiatry

V. Timmermann, L. A. Dejgaard, K. H. Haugaa, A. G. Edwards, J. Sundnes, A. D. McCulloch and S. Wall

An integrative appraisal of mechano-electric feedback mechanisms in the heart

Progress in biophysics and molecular biology

A. G. Edwards and W. E. Louch

Species-Dependent Mechanisms of Cardiac Arrhythmia: A Cellular Focus

Clinical Medicine Insights: Cardiology

M. Maleckar, A. G. Edwards, W. E. Louch and G. T. Lines

Studying dyadic structure–function relationships: a review of current modeling approaches and new insights into ca2+ (mis) handling

Clinical Medicine Insights: Cardiology

V. Timmermann, L. A. Dejgaard, A. D. McCulloch, K. H. Haugaa, A. G. Edwards and S. Wall

Role of Electromechanical Feedback in Stretch Induced Arrhythmias : From Single Myocyte to Multicellular Level

V. Timmermann, S. Wall, J. Sundnes, T. A. Quinn and A. G. Edwards

Integrated Mechanisms of Mechano-Electric Feedback in Ischemic Arrhythmogenesis

I. G. M. van Herck, R. S. Vicens, H. Arevalo, J. Koivumäki, B. H. Bentzen and A. G. Edwards

Small conductance calcium activated potassium channel: pharmacology and binding scheme for in silico model

V. Timmermann, A. G. Edwards, J. Sundnes, A. D. McCulloch, S. Wall and T. A. Quinn

Integrated Mechanisms of Mechano-Electric feedback in Ischemic Arrhythmogenesis

Bergen, Norway

A. G. Edwards, J. E. Hake, A. P. Michailova, M. Hoshijima and A. D. McCulloch

Calcium Signaling in Cardiomyocyte Models With Realistic Geometries (7th Edition)

Cardiac Electrophysiology: From Cell to Bedside

S. Morotti, A. D. McCulloch, D. M. Bers, A. G. Edwards and E. Grandi

Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes

Journal of Molecular and Cellular Cardiology

A. Tveito, G. T. Lines, A. G. Edwards and A. D. McCulloch

Computing rates of Markov models of voltage-gated ion channels by inverting partial differential equations governing the probability density functions of the conducting and non-conducting states

Mathematical Biosciences

V. Timmermann, A. G. Edwards, J. Sundnes, A. D. McCulloch and S. Wall

Role of Electromechanical Feedback in Mitral Valve Prolapse Arrhythmia

M. J. Shattock, M. Ottolia, D. M. Bers, M. P. Blaustein, A. Boguslavskyi, J. Bossuyt, J. H. Bridge, Y. Chen-Izu, C. E. Clancy and A. G. Edwards

Na+/Ca2+ exchange and Na+/K+-ATPase in the heart

The Journal of Physiology

S. Morotti, A. D. McCulloch, D. M. Bers, A. G. Edwards and E. Grandi

Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes

Journal of Molecular and Cellular Cardiology

A. H. Ottesen, C. R. Carlson, A. G. Edwards, O. J. Landsverk, R. Johansen, M. K. Moe, M. Bjøraas, M. Stridsberg, T. Omland, G. Christensen and H. Røsjø

Secretoneurin, a Novel Endogenous CaMKII Inhibitor, Augments Cardiomyocyte Calcium Handling and Inhibits Arrhythmogenic Calcium Release

Biophysical Journal

S. Morotti, A. D. McCulloch, D. M. Bers, A. G. Edwards and E. Grandi

Ranolazine Prevents Phase-3 Early Afterdepolarizations in Human Atrial Myocytes by Inhibiting Na Current Non-Equilibrium Reactivation

Biophysical Society annual meeting

P. M. Kekenes-Huskey, A. G. Edwards, J. E. Hake, A. P. Michailova, A. J. McCammon and A. D. McCulloch

A Markov-State Model for the Regulation of the Sarcoplasmic Reticulum Ca2+ ATPase by Phospholamban

Annual meeting in Biophysical society

A. G. Edwards, E. Grandi, J. E. Hake, S. Patel, P. Li, S. Miyamoto, J. H. Omens, J. H. Brown, D. M. Bers and A. D. McCulloch

Non-equilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle

Circulation: Arrhythmia and Electrophysiology

K. P. Vincent, A. D. McCulloch and A. G. Edwards

Toward a hierarchy of mechanisms in CaMKII-mediated arrhythmia

Frontiers in Pharmacology

S. Morotti, A. G. Edwards, A. D. McCulloch, D. M. Bers and E. Grandi

A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII

The Journal of physiology

E. Grandi, A. G. Edwards, A. W. Herren and D. M. Bers

CaMKII comes of age in cardiac health and disease.

Frontiers in pharmacology

E. Pfeiffer, A. Wright, A. G. Edwards, J. Stowe, K. McNall, J. Tan, I. Niesman, H. Patel, D. Roth, J. Omens and A. D. McCulloch

Caveolae in ventricular myocytes are required for stretch-dependent conduction slowing

Journal of Molecular and Cellular Cardiology

K. P. Vincent, A. D. McCulloch and A. G. Edwards

Toward a hierarchy of mechanisms in CaMKII-mediated arrhythmia

Frontiers in Pharmacology

E. Grandi, A. G. Edwards, A. W. Herren and D. M. Bers

CaMKII comes of age in cardiac health and disease

Frontiers in Pharmacology

S. Morotti, A. G. Edwards, A. D. McCulloch, D. M. Bers and E. Grandi

A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII

The Journal of Physiology

A. P. Michailova, A. G. Edwards, J. E. Hake, M. Hoshijima and A. D. McCulloch

Calcium Signaling in Cardiomyocyte Models With Realistic Geometries (6th Edition)

Cardiac Electrophysiology: From Cell to Bedside

D. Westenbrink, A. G. Edwards, A. D. McCulloch and J. H. Brown

The promise of CaMKII inhibition for heart disease: preventing heart failure and arrhythmias

Expert opinion on therapeutic targets

D. Westenbrink, A. G. Edwards and S. Miyamoto

Conference report from the 2012 AHA scientific sessions in Los Angeles

Expert Opinion on Therapeutic Targets

J. E. Hake, A. G. Edwards, Z. Yu, P. M. Kekenes-Huskey, A. P. Michailova, A. J. McCammon, M. J. Holst, M. Hoshijima and A. D. McCulloch

Modeling Cardiac Calcium Sparks in a Three-Dimensional Reconstruction of a Calcium Release Unit

The Journal of Physiology

A. Tveito, G. T. Lines, A. G. Edwards, M. Maleckar, A. P. Michailova, J. E. Hake and A. D. McCulloch

Slow Calcium-Depolarization-Calcium Waves May Initiate Fast Local Depolarization Waves in Ventricular Tissue

Progress in Biophysics and Molecular Biology

A. Tveito, G. T. Lines, J. E. Hake and A. G. Edwards

Instabilities of the Resting State in a Mathematical Model of Calcium Handling in Cardiac Myocytes

Mathematical Biosciences

J. E. Hake, A. G. Edwards, Z. Yu, P. M. Kekenes-Huskey, A. P. Michailova, A. J. McCammon, M. J. Holst, M. Hoshijima and A. D. McCulloch

Modeling Calcium Sparks in a Three-Dimensional Reconstruction of a Cardiac Calcium Release Unit

A. G. Edwards, J. E. Hake, J. H. Brown and A. D. McCulloch

βAR-Stimulation Causes EADs But Not DADs in Pre-Failure CAMKIIδC Transgenic Myocytes

Biophysical Society annual meeting

A. C. Lim, E. P. Homestead, A. G. Edwards, T. C. Carver, R. Kram and W. C. Byrnes

Measuring changes in aerodynamic/rolling resistances by cycle-mounted power meters

Medicine and science in sports and exercise

A. J. Donato and A. G. Edwards

What for nature, and who to nurture?

Journal of Applied Physiology

A. J. Donato and A. G. Edwards

What for nature, and who to nurture?

Journal of Applied Physiology

A. G. Edwards, J. O. Hill, W. C. Byrnes and R. C. Browning

Accuracy of optimized branched algorithms to assess activity-specific PAEE

Medicine and science in sports and exercise

A. G. Edwards, A. J. Donato, L. A. Lesniewski, R. A. Gioscia, D. R. Seals and R. L. Moore

Life-long caloric restriction elicits pronounced protection of the aged myocardium: a role for AMPK

Mechanisms of ageing and development

A. G. Edwards, A. J. Donato, L. A. Lesniewski, R. A. Gioscia, D. R. Seals and R. L. Moore

Life-long caloric restriction elicits pronounced protection of the aged myocardium: a role for AMPK

Mechanisms of Aging and Development

A. G. Edwards, M. L. Rees, R. A. Gioscia, D. K. Zachman, J. M. Lynch, J. C. Browder, A. J. Chicco and R. L. Moore

PKC-permitted elevation of sarcolemmal KATP concentration may explain female-specific resistance to myocardial infarction

The Journal of Physiology

A. G. Edwards and W. C. Byrnes

Aerodynamic characteristics as determinants of the drafting effect in cycling.

Medicine and science in sports and exercise