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2022
K. H. Jæger, A. G. Edwards, W. R. Giles and A. Tveito. "Arrhythmogenic influence of mutations in a myocyte‑based computational model of the pulmonary vein sleeve." Nature Scientific Reports 12 (2022): 7040.
X. Zhang, H. Ni, S. Morotti, C. E. R. Smith, D. Sato, W. E. Louch, A. G. Edwards and E. Grandi. "Mechanisms of spontaneous Ca 2+ release‐mediated arrhythmia in a novel 3D human atrial myocyte model: I. Transverse‐axial tubule variation." The Journal of Physiology (2022).
X. Zhang, C. E. R. Smith, S. Morotti, A. G. Edwards, D. Sato, W. E. Louch, H. Ni and E. Grandi. "Mechanisms of spontaneous Ca2+ release‐mediated arrhythmia in a novel 3D human atrial myocyte model: II Ca2+‐handling protein variation." The Journal of Physiology 116 (2022).
N. Huebsch, B. Charrez, G. Neiman, B. Siemons, S. C. Boggess, S. Wall, V. Charwat, K. H. Jæger, D. Cleres, Å. Telle et al. "Metabolically driven maturation of human-induced-pluripotent-stem-cell-derived cardiac microtissues on microfluidic chips." Nature Biomedical Engineering 6, no. 4 (2022): 372-388.
V. Charwat, B. Charrez, B. A. Siemons, H. Finsberg, K. H. Jæger, A. G. Edwards, N. Huebsch, S. Wall, E. Miller, A. Tveito et al. "Validating the Arrhythmogenic Potential of High-, Intermediate-, and Low-Risk Drugs in a Human-Induced Pluripotent Stem Cell-Derived Cardiac Microphysiological System." ACS Pharmacology & Translational Science 5, no. 8 (2022): 652-667.
2021
A. G. Edwards, J. van den Brink and A. D. McCulloch. "Calcium Signaling in Cardiomyocyte Models With Realistic Geometries." In Zipes and Jalife's Cardiac Electrophysiology: From Cell to Bedside, edited by J. Jalife and W. G. Stevenson, 362-375. 8th ed. Vol. 1. Elsevier, 2021.
K. H. Jæger, A. G. Edwards, W. R. Giles and A. Tveito. "A computational method for identifying an optimal combination of existing drugs to repair the action potentials of SQT1 ventricular myocytes." PLoS Computational Biology 17 (2021): e1009233.
K. H. Jæger, A. G. Edwards, W. R. Giles and A. Tveito. "From Millimeters to Micrometers; Re-introducing Myocytes in Models of Cardiac Electrophysiology." Frontiers in Physiology 12 (2021): 763584.
B. Charrez, V. Charwat, B. Siemons, I. Goswami, C. Sakolish, Y. Luo, H. Finsberg, A. G. Edwards, E. Miller, I. Rusyn et al. "Heart Muscle Microphysiological System for Cardiac Liability Prediction of Repurposed COVID-19 Therapeutics." Frontiers in Pharmacology 12 (2021): 684252.
B. Charrez, V. Charwat, B. Siemons, H. Finsberg, E. Miller, A. G. Edwards and K. E. Healy. "In vitro safety “clinical trial” of the cardiac liability of drug polytherapy." Clinical and Translational Science 14, no. 3 (2021): 1155-1165.
2020
V. Timmermann, A. T. Quinn, J. Sundnes, S. Wall, A. D. McCulloch and A. G. Edwards. "A computational study on integrated mechanisms of mechano-electric feedback in ischemic arrhythmogenesis." SAGE (2020).
B. Charrez, V. Charwat, B. Siemons, H. Finsberg, E. Miller, A. G. Edwards and K. E. Healy. "In Vitro Safety “Clinical Trial” of the Cardiac Liability of Hydroxychloroquine and Azithromycin as COVID19 Polytherapy." Clinical Pharmacology & Therapeutics (2020).
2019
X. Shen, J. van den Brink, Y. Hou, D. Colli, C. Le, T. R. Kolstad, N. MacQuaide, C. R. Carlson, P. M. Kekenes-Huskey, A. G. Edwards et al. "3D dSTORM imaging reveals novel detail of ryanodine receptor localization in rat cardiac myocytes." The Journal of Physiology 597, no. 2 (2019): 399-418.
V. Timmermann, A. G. Edwards, S. Wall, J. Sundnes and A. D. McCulloch. "Arrhythmogenic current generation by myofilament-triggered Ca2+ release and sarcomere heterogeneity." Biophysical Journal 117, no. 12 (2019): 2471-2485.
V. Timmermann, J. Sundnes, S. Wall, A. D. McCulloch and A. G. Edwards. A one-dimensional computational study of mechano-electric feedback and arrhythmogenic current generation In Gordon Research Conference "Cardiac Arrhythmia Mechanisms", Barga, Italy., 2019.
K. H. Jæger, A. G. Edwards, A. D. McCulloch and A. Tveito. "Properties of cardiac conduction in a cell-based computational model." PLoS Computational Biology 15, no. 5 (2019).
2018
M. Vagos, I. G. M. van Herck, J. Sundnes, H. Arevalo, A. G. Edwards and J. Koivumäki. "Computational Modeling of Electrophysiology and Pharmacotherapy of Atrial Fibrillation: Recent Advances and Future Challenges." Frontiers in Physiology 9 (2018): 1221.
V. Timmermann, J. Sundnes, S. Wall, A. D. McCulloch and A. G. Edwards. A computational study of the contribution of mechano-electric feedback to arrhythmogenic current generation In Berlin, Germany. Heart by Numbers, Biophysical Society, 2018.
A. Tveito, K. H. Jæger, N. Huebsch, B. Charrez, A. G. Edwards, S. Wall and K. E. Healy. "Inversion and computational maturation of drug response using human stem cell derived cardiomyocytes in microphysiological systems." Nature Scientific Reports 8 (2018).
T. R. Kolstad, J. van den Brink, N. MacQuaide, P. K. Lunde, M. Frisk, J. M. Aronsen, E. S. Norden, A. Cataliotti, I. Sjaastad, O. M. Sejersted et al. "Ryanodine Receptor Dispersion Disrupts Ca2+-Release in Failing Cardiac Myocytes." eLife 7 (2018): e39427.
2017
A. Tveito, K. H. Jæger, G. T. Lines, Ł. Paszkowski, J. Sundnes, A. G. Edwards, T. Mäki-Marttunen, G. Halnes and G. T. Einevoll. "An Evaluation of the Accuracy of Classical Models for Computing the Membrane Potential and Extracellular Potential for Neurons." Frontiers in Computational Neuroscience 11 (2017): 27.
V. Timmermann, S. Wall, J. Sundnes, T. A. Quinn and A. G. Edwards. Integrated Mechanisms of Mechano-Electric Feedback in Ischemic Arrhythmogenesis. Oslo, Norway, 2017.
V. Timmermann, A. G. Edwards, J. Sundnes, A. D. McCulloch, S. Wall and T. A. Quinn. Integrated Mechanisms of Mechano-Electric feedback in Ischemic Arrhythmogenesis In Bergen, Norway., 2017.
V. Timmermann, L. A. Dejgaard, K. H. Haugaa, A. G. Edwards, J. Sundnes, A. D. McCulloch and S. Wall. "An integrative appraisal of mechano-electric feedback mechanisms in the heart." Progress in biophysics and molecular biology 130 (2017): 404-417.PDF icon 1-s2.0-s0079610717300470-main.pdf (9.57 MB)
T. Mäki-Marttunen, G. T. Lines, A. G. Edwards, A. Tveito, A. M. Dale, G. T. Einevoll and O. A. Andreassen. "Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling." Translational Psychiatry 7 (2017): 5.

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