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2022
K. H. Jæger, A. G. Edwards, W. R. Giles and A. Tveito. "Arrhythmogenic influence of mutations in a myocyte‑based computational model of the pulmonary vein sleeve." Nature Scientific Reports 12 (2022): 7040.
W. E. Louch, H. Perdreau-Dahl and A. G. Edwards. "Image-Driven Modeling of Nanoscopic Cardiac Function: Where Have We Come From, and Where Are We Going?" Frontiers in Physiology 13 (2022).PDF icon louch_et_al-2022-frontiers_in_physiology.pdf (4.25 MB)
X. Zhang, H. Ni, S. Morotti, C. E. R. Smith, D. Sato, W. E. Louch, A. G. Edwards and E. Grandi. "Mechanisms of spontaneous Ca 2+ release‐mediated arrhythmia in a novel 3D human atrial myocyte model: I. Transverse‐axial tubule variation." The Journal of Physiology (2022).
X. Zhang, C. E. R. Smith, S. Morotti, A. G. Edwards, D. Sato, W. E. Louch, H. Ni and E. Grandi. "Mechanisms of spontaneous Ca2+ release‐mediated arrhythmia in a novel 3D human atrial myocyte model: II Ca2+‐handling protein variation." The Journal of Physiology 116 (2022).
N. Huebsch, B. Charrez, G. Neiman, B. Siemons, S. C. Boggess, S. Wall, V. Charwat, K. H. Jæger, D. Cleres, Å. Telle et al. "Metabolically driven maturation of human-induced-pluripotent-stem-cell-derived cardiac microtissues on microfluidic chips." Nature Biomedical Engineering 6, no. 4 (2022): 372-388.
X. Shen, J. van den Brink, A. Bergan-Dahl, T. R. Kolstad, E. S. Norden, Y. Hou, M. Laasmaa, Y. Aguilar-Sanchez, A. P. Quick, E. K. S. Espe et al. "Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes." eLife 11 (2022).
V. Charwat, B. Charrez, B. A. Siemons, H. Finsberg, K. H. Jæger, A. G. Edwards, N. Huebsch, S. Wall, E. Miller, A. Tveito et al. "Validating the Arrhythmogenic Potential of High-, Intermediate-, and Low-Risk Drugs in a Human-Induced Pluripotent Stem Cell-Derived Cardiac Microphysiological System." ACS Pharmacology & Translational Science 5, no. 8 (2022): 652-667.
2021
A. G. Edwards, J. van den Brink and A. D. McCulloch. "Calcium Signaling in Cardiomyocyte Models With Realistic Geometries." In Zipes and Jalife's Cardiac Electrophysiology: From Cell to Bedside, edited by J. Jalife and W. G. Stevenson, 362-375. 8th ed. Vol. 1. Elsevier, 2021.
K. H. Jæger, A. G. Edwards, W. R. Giles and A. Tveito. "A computational method for identifying an optimal combination of existing drugs to repair the action potentials of SQT1 ventricular myocytes." PLoS Computational Biology 17 (2021): e1009233.
K. H. Jæger, A. G. Edwards, W. R. Giles and A. Tveito. "From Millimeters to Micrometers; Re-introducing Myocytes in Models of Cardiac Electrophysiology." Frontiers in Physiology 12 (2021): 763584.
B. Charrez, V. Charwat, B. Siemons, I. Goswami, C. Sakolish, Y. Luo, H. Finsberg, A. G. Edwards, E. Miller, I. Rusyn et al. "Heart Muscle Microphysiological System for Cardiac Liability Prediction of Repurposed COVID-19 Therapeutics." Frontiers in Pharmacology 12 (2021): 684252.
B. Charrez, V. Charwat, B. Siemons, H. Finsberg, E. Miller, A. G. Edwards and K. E. Healy. "In vitro safety “clinical trial” of the cardiac liability of drug polytherapy." Clinical and Translational Science 14, no. 3 (2021): 1155-1165.
A. G. Edwards, H. Mørk, M. K. Stokke, D. B. Lipsett, I. Sjaastad, S. Richard, O. M. Sejersted and W. E. Louch. "Sarcoplasmic Reticulum Calcium Release Is Required for Arrhythmogenesis in the MouseData_Sheet_1.pdf." Frontiers in Physiology 129247113307196118101757330290951073619410426311810310255549995881112965921565931388107972921061031069987209102119109419102782 (2021).
A. F. Iseppe, H. Ni, S. Zhu, X. Zhang, R. Coppini, P. Yang, U. Srivatsa, C. E. Clancy, A. G. Edwards, S. Morotti et al. "Sex‐Specific Classification of Drug‐Induced Torsade de Pointes Susceptibility Using Cardiac Simulations and Machine Learning." Clinical Pharmacology & Therapeutics 1105970708108167, no. 2 (2021): 380-391.

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