K. H. Jæger, A. G. Edwards, W. R. Giles and A. Tveito. "Arrhythmogenic influence of mutations in a myocyte‑based computational model of the pulmonary vein sleeve." Nature Scientific Reports 12 (2022): 7040.

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W. E. Louch, H. Perdreau-Dahl and A. G. Edwards. "Image-Driven Modeling of Nanoscopic Cardiac Function: Where Have We Come From, and Where Are We Going?" Frontiers in Physiology 13 (2022).

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louch_et_al-2022-frontiers_in_physiology.pdf (4.25 MB)

X. Zhang, H. Ni, S. Morotti, C. E. R. Smith, D. Sato, W. E. Louch, A. G. Edwards and E. Grandi. "Mechanisms of spontaneous Ca ²⁺ release‐mediated arrhythmia in a novel 3D human atrial myocyte model: I. Transverse‐axial tubule variation." The Journal of Physiology (2022).

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X. Zhang, C. E. R. Smith, S. Morotti, A. G. Edwards, D. Sato, W. E. Louch, H. Ni and E. Grandi. "Mechanisms of spontaneous Ca²⁺ release‐mediated arrhythmia in a novel 3D human atrial myocyte model: II Ca²⁺‐handling protein variation." The Journal of Physiology 116 (2022).

• Google Scholar
• BibTeX

N. Huebsch, B. Charrez, G. Neiman, B. Siemons, S. C. Boggess, S. Wall, V. Charwat, K. H. Jæger, D. Cleres, Å. Telle et al. "Metabolically driven maturation of human-induced-pluripotent-stem-cell-derived cardiac microtissues on microfluidic chips." Nature Biomedical Engineering 6, no. 4 (2022): 372-388.

• Google Scholar
• BibTeX

X. Shen, J. van den Brink, A. Bergan-Dahl, T. R. Kolstad, E. S. Norden, Y. Hou, M. Laasmaa, Y. Aguilar-Sanchez, A. P. Quick, E. K. S. Espe et al. "Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes." eLife 11 (2022).

• Google Scholar
• BibTeX

V. Charwat, B. Charrez, B. A. Siemons, H. Finsberg, K. H. Jæger, A. G. Edwards, N. Huebsch, S. Wall, E. Miller, A. Tveito et al. "Validating the Arrhythmogenic Potential of High-, Intermediate-, and Low-Risk Drugs in a Human-Induced Pluripotent Stem Cell-Derived Cardiac Microphysiological System." ACS Pharmacology & Translational Science 5, no. 8 (2022): 652-667.

• Google Scholar
• BibTeX

A. G. Edwards, J. van den Brink and A. D. McCulloch. "Calcium Signaling in Cardiomyocyte Models With Realistic Geometries." In Zipes and Jalife's Cardiac Electrophysiology: From Cell to Bedside, edited by J. Jalife and W. G. Stevenson, 362-375. 8th ed. Vol. 1. Elsevier, 2021.

• Google Scholar
• BibTeX

K. H. Jæger, A. G. Edwards, W. R. Giles and A. Tveito. "A computational method for identifying an optimal combination of existing drugs to repair the action potentials of SQT1 ventricular myocytes." PLoS Computational Biology 17 (2021): e1009233.

• Google Scholar
• BibTeX

K. H. Jæger, A. G. Edwards, W. R. Giles and A. Tveito. "From Millimeters to Micrometers; Re-introducing Myocytes in Models of Cardiac Electrophysiology." Frontiers in Physiology 12 (2021): 763584.

• Google Scholar
• BibTeX

B. Charrez, V. Charwat, B. Siemons, I. Goswami, C. Sakolish, Y. Luo, H. Finsberg, A. G. Edwards, E. Miller, I. Rusyn et al. "Heart Muscle Microphysiological System for Cardiac Liability Prediction of Repurposed COVID-19 Therapeutics." Frontiers in Pharmacology 12 (2021): 684252.

• Google Scholar
• BibTeX

B. Charrez, V. Charwat, B. Siemons, H. Finsberg, E. Miller, A. G. Edwards and K. E. Healy. "In vitro safety “clinical trial” of the cardiac liability of drug polytherapy." Clinical and Translational Science 14, no. 3 (2021): 1155-1165.

• Google Scholar
• BibTeX

A. G. Edwards, H. Mørk, M. K. Stokke, D. B. Lipsett, I. Sjaastad, S. Richard, O. M. Sejersted and W. E. Louch. "Sarcoplasmic Reticulum Calcium Release Is Required for Arrhythmogenesis in the MouseData_Sheet_1.pdf." Frontiers in Physiology 129247113307196118101757330290951073619410426311810310255549995881112965921565931388107972921061031069987209102119109419102782 (2021).

• Google Scholar
• BibTeX

A. F. Iseppe, H. Ni, S. Zhu, X. Zhang, R. Coppini, P. Yang, U. Srivatsa, C. E. Clancy, A. G. Edwards, S. Morotti et al. "Sex‐Specific Classification of Drug‐Induced Torsade de Pointes Susceptibility Using Cardiac Simulations and Machine Learning." Clinical Pharmacology & Therapeutics 1105970708108167, no. 2 (2021): 380-391.

• Google Scholar
• BibTeX

X. Shen, T. R. Kolstad, J. van den Brink, M. Frisk, Y. Hou, E. Norden, A. G. Edwards, I. Sjaastad, C. Soeller and W. E. Louch. 3D Dstorm Imaging Reveals Camkii-Dependent Dispersal of Ryanodine Receptor Clusters in Failing Rat Cardiomyocytes In Biophysical Journal. Biophysical Journal: Cell Press, 2020.

• Google Scholar
• BibTeX

V. Timmermann, A. T. Quinn, J. Sundnes, S. Wall, A. D. McCulloch and A. G. Edwards. "A computational study on integrated mechanisms of mechano-electric feedback in ischemic arrhythmogenesis." SAGE (2020).

• Google Scholar
• BibTeX

B. Charrez, V. Charwat, B. Siemons, H. Finsberg, E. Miller, A. G. Edwards and K. E. Healy. "In Vitro Safety “Clinical Trial” of the Cardiac Liability of Hydroxychloroquine and Azithromycin as COVID19 Polytherapy." Clinical Pharmacology & Therapeutics (2020).

• Google Scholar
• BibTeX

T. Mäki-Marttunen, N. Iannella, A. G. Edwards, G. T. Einevoll and K. T. Blackwell. "A unified computational model for cortical post-synaptic plasticity." eLife 9 (2020).

• Google Scholar
• BibTeX

X. Shen, J. van den Brink, Y. Hou, D. Colli, C. Le, T. R. Kolstad, N. MacQuaide, C. R. Carlson, P. M. Kekenes-Huskey, A. G. Edwards et al. "3D dSTORM imaging reveals novel detail of ryanodine receptor localization in rat cardiac myocytes." The Journal of Physiology 597, no. 2 (2019): 399-418.

• Google Scholar
• BibTeX

V. Timmermann, A. G. Edwards, S. Wall, J. Sundnes and A. D. McCulloch. "Arrhythmogenic current generation by myofilament-triggered Ca2+ release and sarcomere heterogeneity." Biophysical Journal 117, no. 12 (2019): 2471-2485.

• Google Scholar
• BibTeX

T. Mäki-Marttunen, T. Kaufmann, T. Elvs\aashagen, A. Devor, S. Djurovic, L. T. Westlye, M. Linne, M. Rietschel, D. Schubert, S. Borgwardt et al. "Biophysical Psychiatry—How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders." Frontiers in psychiatry 10 (2019).

• Google Scholar
• BibTeX

revscz.pdf (1.2 MB)

V. Timmermann, J. Sundnes, S. Wall, A. D. McCulloch and A. G. Edwards. A one-dimensional computational study of mechano-electric feedback and arrhythmogenic current generation In Gordon Research Conference "Cardiac Arrhythmia Mechanisms", Barga, Italy., 2019.

• Google Scholar
• BibTeX

K. H. Jæger, A. G. Edwards, A. D. McCulloch and A. Tveito. "Properties of cardiac conduction in a cell-based computational model." PLoS Computational Biology 15, no. 5 (2019).

• Google Scholar
• BibTeX

T. Mäki-Marttunen, F. Krull, F. Bettella, E. Hagen, S. Næss, T. V. Ness, T. Moberget, T. Elvs\aashagen, C. Metzner, A. Devor et al. "Alterations in Schizophrenia-Associated Genes Can Lead to Increased Power in Delta Oscillations." Cerebral Cortex 29 (2018): 875-891.

• Google Scholar
• BibTeX

scznet_withfigs.pdf (5.14 MB)

M. Vagos, I. G. M. van Herck, J. Sundnes, H. Arevalo, A. G. Edwards and J. Koivumäki. "Computational Modeling of Electrophysiology and Pharmacotherapy of Atrial Fibrillation: Recent Advances and Future Challenges." Frontiers in Physiology 9 (2018): 1221.

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