Cerebrospinal fluid (CSF) provides a protective cushioning to the brain and the spinal cord, and serves an important role in nutrient transport and waste removal, essential for maintaining normal neuronal function. Homeostatic feedback mechanisms are responsible for the strict regulation of CSF formation, composition, volume, turnover, and flow (Bothwell et al., 2019). Dysregulation of these homeostatic feedback mechanisms during certain neurological diseases such as stroke, brain trauma, hydrocephalus and idiopathic intracranial hypertension (IIH) can cause CSF volume to rise. This can be life threatening, as it leads to an increase in intracranial pressure (ICP). Control of ICP is achieved via highly invasive procedures. Development of non-invasive treatments such as pharmacological agents is hampered by a lack of suitable models and incomplete understanding of the underlying pathophysiology. This Research Topic aimed to collect emerging evidence and novel perspectives on CSF dynamics and ICP elevation in neurological disease to highlight new developments in this field.