|Authors||A. K. Diem and K. Valen-Sendstad|
|Title||Modelling Advection-Based Nanoparticle Drug Delivery To The Left Ventricle Using A Splitting Method For Advection-Diffusion-Kinetics|
|Project(s)||CUPIDO: Cardio Ultraefficient nanoParticles for Inhalation of Drug prOducts|
|Publication Type||Talks, contributed|
|Year of Publication||2019|
|Location of Talk||Summer Biomechanics, Bioengineering, and Biotransport Conference|
The use of nanoparticles (NP) target drug delivery directly to the heart for treatment of diseases via nanoparticles (NP) has been a major goal of cardiovascular research since the early 2000s. Recently, such NP delivery systems based on non-invasive administration via inhalation have successfully been developed and shown to reduce heart failure in mice. However, the transition of such innovative technology to larger animals and subsequently humans, requires careful optimisation of physico-chemical parameters of the NP, in order to achieve efficient distribution throughout the tissue. We address this challenge by presenting a finite-element model of NP delivery via perfusion through the myocardium in the left ventricle (LV), which presents its own unique challenges: The discrepancy of scales between the size of the LV, blood vessels perfusing the LV, and NP requires the development of efficient averaging methods to effectively reduce simulation times. To achieve this, perfusion is represented by a three-compartment porous media continuum model based on Darcy's law, while NP delivery is approximated by splitting advection and diffusion kinetics across compartments. Using these methods we demonstrate efficient simulation of NP delivery to the myocardium.