Glenn Terje Lines
Senior Research Scientist
- Department
- Computational Physiology
- Organisation
- Simula Research Laboratory
- glennli@simula.no
Publications
2023
Journal Articles
P. Lakrisenko, P. Stapor, S. Grein, L. Paszkowski, D. Pathirana, F. Fröhlich, G. T. Lines, D. Weindl and J. Hasenauer
Efficient computation of adjoint sensitivities at steady-state in ODE models of biochemical reaction networks
PLOS Computational Biology
A. H. Erhardt, K. Tsaneva-Atanasova, G. T. Lines and E. A. Martens
Editorial: Dynamical Systems, PDEs and Networks for Biomedical Applications: Mathematical Modeling, Analysis and Simulations
Frontiers in Physics
2022
Journal Articles
T. R. Karlsen, M. B. Olsen, X. Y. Kong, K. Yang, A. Quiles-Jiménez, P. Kroustallaki, S. Holm, G. T. Lines, P. Aukrust, T. Skarpengland, M. Bjørås, T. B. Dahl, H. Nilsen, I. Gregersen and B. Halvorsen
NEIL3-deficient bone marrow displays decreased hematopoietic capacity and reduced telomere length
Biochemistry and Biophysics Reports
Book Chapters
A. M. Bruaset, G. T. Lines and J. Sundnes
Data aggregation and anonymization for mathematical modeling and epidemiological studies
Smittestopp - A Case Study on Digital Contact Tracing
2019
Journal Articles
J. Skogestad, G. T. Lines, W. E. Louch, O. M. Sejersted, I. Sjaastad and J. M. Aronsen
Evidence for heterogeneous subsarcolemmal Na+ levels in rat ventricular myocytes
AJP-Heart and Circulatory Physiology
Proceedings, refereed
C. Jarvis, G. T. Lines, J. Langguth, K. Nakajima and X. Cai
Combining algorithmic rethinking and AVX-512 intrinsics for efficient simulation of subcellular calcium signaling
International Conference on Computational Science (ICCS 2019)
G. T. Lines, L. Paszkowski, L. Schmiester, D. Weindl, P. Stapor and J. Hasenauer
Efficient computation of steady states in large-scale ODE models of biochemical reaction networks
8th IFAC Conference on Foundations of Systems Biology in Engineering
2018
Journal Articles
T. R. Kolstad, J. van den Brink, N. MacQuaide, P. K. Lunde, M. Frisk, J. M. Aronsen, E. S. Norden, A. Cataliotti, I. Sjaastad, O. M. Sejersted, A. G. Edwards, G. T. Lines and W. E. Louch
Ryanodine Receptor Dispersion Disrupts Ca2+-Release in Failing Cardiac Myocytes
eLife
A. Tveito, M. Maleckar and G. T. Lines
Computing Optimal Properties of Drugs Using Mathematical Models of Single Channel Dynamics
Computational and Mathematical Biophysics
2017
Journal Articles
M. Maleckar, A. G. Edwards, W. E. Louch and G. T. Lines
Studying dyadic structure–function relationships: a review of current modeling approaches and new insights into ca2+ (mis) handling
Clinical Medicine Insights: Cardiology
T. Mäki-Marttunen, G. T. Lines, A. G. Edwards, A. Tveito, A. M. Dale, G. T. Einevoll and O. A. Andreassen
Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling
Translational Psychiatry
A. Tveito, K. H. Jæger, G. T. Lines, Ł. Paszkowski, J. Sundnes, A. G. Edwards, T. Mäki-Marttunen, G. Halnes and G. T. Einevoll
An Evaluation of the Accuracy of Classical Models for Computing the Membrane Potential and Extracellular Potential for Neurons
Frontiers in Computational Neuroscience
M. Maleckar, A. G. Edwards, W. Louch and G. T. Lines
Studying dyadic structure-function relationships: a review of current modeling approaches and new insights into Ca2+ (mis)handling
Clinical Medicine Insights: Cardiology
2016
Journal Articles
G. T. Lines, B. L. de Oliveira, O. Skavhaug and M. Maleckar
Simple t-wave metrics may better predict early ischemia as compared to st segment
IEEE Transactions on Biomedical Engineering
A. Tveito, G. T. Lines, A. G. Edwards and A. D. McCulloch
Computing rates of Markov models of voltage-gated ion channels by inverting partial differential equations governing the probability density functions of the conducting and non-conducting states
Mathematical Biosciences
G. T. Lines, B. L. de Oliveira, O. Skavhaug and M. Maleckar
Simple T wave metrics may better predict early ischemia as compared to ST segment
IEEE Transactions on Biomedical Engineering
Books
A. Tveito and G. T. Lines
Computing characterizations of drugs for ion channels and receptors using Markov models
2015
Journal Articles
J. Langguth, M. Sourouri, G. T. Lines, S. Baden and X. Cai
Scalable heterogeneous CPU-GPU computations for unstructured tetrahedral meshes
IEEE Micro
2013
Posters
M. Maleckar, G. T. Lines, J. Koivumäki, K. Calloe and J. Cordeiro
NS5806 Partially Restores APD But Fails to Ameliorate Ca2+ Transient Dysfunction in a Computational Model of Canine Heart Failure
Europace 2014
M. Maleckar, G. T. Lines and J. Koivumäki
Ca2+-Transient Dysfunction and Ion Channel Therapy: What Can We Gather From a Computational Model of Canine Heart Failure?
Talks, contributed
G. T. Lines, O. M. Lysaker and B. F. Nielsen
Observability of Ischemia and the Need for Patient Specific Geometrical Models in Inverse ECG
Computing in Cardiology, Zaragoza, Spain
2012
Talks, invited
G. T. Lines and X. Cai
Elements of Scientific Computing
3-day intensive course given at National University of Defence Technology, China, October 16-18
2011
Posters
J. E. Hake, W. E. Louch, K. Haugen, I. Sjaastad, O. M. Sejersted, A. D. McCulloch, A. P. Michailova and G. T. Lines
A Stochastic Model of the Ryanodine Receptor Featuring Coupled Gating and Competitive Binding of Luminal and Cytosolic Ca2+ and Mg2+
2009
Book Chapters
G. T. Lines and J. Sundnes
Computer Simulations of the Heart
Simula Research Laboratory - by thinking constantly about it
2008
Talks, contributed
J. E. Hake and G. T. Lines
Modelling the Mesoscopic Length Scale of EC Coupling: the Diadic Cleft
Invited talk at 'European Conference on Mathematical and Theoretical Biology'
2007
Talks, contributed
J. E. Hake and G. T. Lines
Stochastic Binding of Ca2+ Ions in the Dyadic Cleft Continuous Vs Random Walk Description of Diffusion
Presentation at ICIAM 07
J. E. Hake and G. T. Lines
Stochastic Binding of Ca2+ Ions in the Dyadic Cleft Continuous Vs Random Walk Description of Diffusion
Poster presentation at 5th Annual CHFR Symposium
G. T. Lines
Cardiac Computing at Simula
Talk at CBC Workshop on Biomedical Computing
G. T. Lines
Overview of the Cardiac Computations Project
Talk at CBC, Seminar on Electrophysiology Modeling
2006
Book Chapters
X. Cai and G. T. Lines
Full-Scale Simulation of Cardiac Electrophysiology on Parallel Computers
Numerical Solution of Partial Differential Equations on Parallel Computers
Talks, contributed
M. Hanslien, J. Sundnes, G. T. Lines and A. Tveito
Simulating Electrical Activity in the Heart
Presented at St Jude Medical, Stockholm, Sweeden
B. F. Nielsen, O. M. Lysaker, X. Cai, K. Mardal, C. Tarrou, M. C. MacLachlan, J. Sundnes, G. T. Lines and A. Tveito
Computational Issues in Heart Modeling
Presented at the Johann Radon Institute for Computational and Applied Mathematics, Linz, Austria
2005
Technical reports
B. F. Nielsen, T. S. Ruud, G. T. Lines and A. Tveito
Optimal Monodomain Approximations of the Bidomain Equations
2004
Book Chapters
X. Cai, G. T. Lines and A. Tveito
Parallel Solution of the Bidomain Equations With High Resolutions
Parallel Computing: Software Technology, Algorithms, Architectures & Applications
Technical reports
T. K. Nilssen, L. Ingebrigtsen, M. Hanslien, G. T. Lines and A. Tveito
Resolution Requirements for a 1D Monodomain Model for Simulating
2003
Book Chapters
X. Cai, A. M. Bruaset, H. P. Langtangen, G. T. Lines, K. Samuelsson, W. Shen, A. Tveito and G. Zumbusch
Performance Modeling of PDE Solvers
Advanced Topics in Computational Partial Differential Equations - Numerical Methods and Diffpack Programming
J. Sundnes, G. T. Lines, P. Grøttum and A. Tveito
Electrical Activity in the Human Heart
Advanced Topics in Computational Partial Differential Equations - Numerical Methods and Diffpack Programming
Talks, contributed
G. T. Lines, X. Cai and J. Sundnes
Parallel Algorithms for Simulating the Electrical Activity of the Heart
Presented at the Dagstuhl seminar Challenges in computational science and engineering
X. Cai, G. T. Lines and A. Tveito
Toward Extremely High-Resolution Simulation of Human Heart
Talk at the ParCo 2003 Conference, 2 - 5 September 2003, Dresden, Germany
B. F. Nielsen, G. T. Lines and A. Tveito
Determining the Size and Location of a Myocardial Infarction; a Scientific Computing Framework
Presented at the European Conference on Numerical Mathematics and Advanced Applications, Prague, Czech Republic
G. T. Lines, B. F. Nielsen, A. Tveito, J. Sundnes, P. Grøttum, X. Cai and K. Mardal
Computing the Electrical Activity in the Human Heart
Presented at the Centre of Mathematics for Applications, Oslo
A. Tveito, G. T. Lines, J. Sundnes, B. F. Nielsen, P. Grøttum, X. Cai and K. Mardal
Computing the Electrical Activity in the Human Heart
Presented at the European Conference on Numerical Mathematics and Advanced Applications, Prague, Czech Republic
A. Tveito, G. T. Lines, B. F. Nielsen, J. Sundnes, P. Grøttum, X. Cai and K. Mardal
Computing the Heart
Presented at the 21st CAD-FEM users' meeting 2003 - International congress on FEM technology, Potsdam, Germany
2001
Technical reports
G. T. Lines, X. Cai and A. Tveito
A Parallel Solution of the Bidomain Equations Modeling the Electrical Activity of the Heart
Talks, contributed
J. Sundnes, G. T. Lines, K. Mardal and A. Tveito
On Numerical Techniques for the Bidomain Model
Presented at the SIAM Annual meeting, San Diego, California
2000
Technical reports
J. Sundnes, G. T. Lines and A. Tveito
An Investigation of Different Solvers for Stiff ODE Systems
Talks, contributed
J. Sundnes, G. T. Lines and A. Tveito
Efficient Solution of ODEs Modeling Electrical Activity in Cardiac Cells
DIFTA seminar, Norwegian University of Science and Technology
1999
PhD Thesis
G. T. Lines
Simulating the Electrical Activity in the Heart - a Bidomain Model of the Ventrciles Embedded in a Torso
1998
Technical reports
X. Cai, A. M. Bruaset, H. P. Langtangen, G. T. Lines, K. Samuelsson, W. Shen, A. Tveito and G. Zumbusch
Performance Modeling of PDE Solvers
1996
Book Chapters
G. T. Lines and T. Kavli
The Equivalence of Spline Models and Fuzzy Logic Applied to Model Construction and Interpretation
Neural Adaptive Control Theory