Kimberly McCabe

M. V. Hernández, K. J. McCabe and P. Rangamani

Synaptic cleft geometry modulates NMDAR opening probability by tuning neurotransmitter residence time

Biophysical Journal

K. J. McCabe, N. Forsch, A. G. Edwards and M. Maleckar

Summer School in Computational Physiology: A Collaborative Course in Modeling Excitable Tissues

The Biophysicist

A. Teitgen, M. T. Hock, K. J. McCabe, M. C. Childers, G. Huber, B. Marzban, D. Beard, A. J. McCammon, M. Regnier and A. D. McCulloch

Multiscale modeling shows how 2’-deoxy-ATP rescues ventricular function in heart failure

PNAS

Computational Physiology: Simula Summer School 2023 − Student Reports

M. T. Hock, A. Teitgen, K. J. McCabe, S. P. Hirakis, G. Huber, M. Regnier, R. E. Amaro, A. J. McCammon and A. D. McCulloch

Multiscale computational modeling of the effects of 2’-deoxy-ATP on cardiac muscle calcium handling

Journal of Applied Physics

Computational Physiology: Simula Summer School 2022− Student Reports

M. H. Mesa, J. van den Brink, W. E. Louch, K. J. McCabe and P. Rangamani

Nanoscale organization of ryanodine receptor distribution and phosphorylation pattern determines the dynamics of calcium sparks

PLOS Computational Biology

Computational Physiology: Simula Summer School 2021 − Student Reports

K. J. McCabe and P. Rangamani

Computational modeling approaches to cAMP/PKA signaling in cardiomyocytes

Journal of Molecular and Cellular Cardiology

K. J. McCabe, Y. Aboelkassem, A. Teitgen, G. Huber, A. J. McCammon, M. Regnier and A. D. McCulloch

Predicting the effects of dATP on cardiac contraction using multiscale modeling of the sarcomere

Archives of Biochemistry and Biophysics

K. J. McCabe, Y. Aboelkassem, A. Teitgen, M. Regnier and A. D. McCulloch

Multiscale modelling determines mechanisms of action for 2'-deoxy-ATP, a myosin activating therapeutic for heart failure

VPH 2020, Paris, France (Virtual)

Y. Aboelkassem, K. J. McCabe, G. Huber, M. Regnier, A. J. McCammon and A. D. McCulloch

A Stochastic Multiscale Model of Cardiac Thin Filament Activation Using Brownian-Langevin Dynamics

Biophysical Journal

Y. Aboelkassem, J. D. Powers, K. J. McCabe and A. D. McCulloch

Multiscale Models of Cardiac Muscle Biophysics and Tissue Remodeling in Hypertrophic Cardiomyopathies

Current Opinion in Biomedical Engineering

J. D. Powers, C. Yuan, K. J. McCabe, J. D. Murray, M. C. Childers, G. Flint, F. Moussavi-Harami, S. Mohran, R. Castillo, C. Zuzek, W. Ma, V. Daggett, A. D. McCulloch, T. C. Irving and M. Regnier

Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin

Proceedings of the National Academy of Sciences

K. J. McCabe, Y. Aboelkassem, S. Dewan, M. Regnier and A. D. McCulloch

A Markov State Model of the Sarcomere to Explain the Effects of dATP on Cardiac Contraction

Y. Aboelkassem, K. J. McCabe, G. Huber, J. Sundnes and A. D. McCulloch

Turning the Azimuthal Motions of Adjacent Tropomyosins into a Coupled N-body Problem in a Brownian Model of Cardiac Thin Filament Activation

Biophysical Journal

S. Dewan, K. J. McCabe, M. Regnier and A. D. McCulloch

Insights and Challenges of Multi-Scale Modeling of Sarcomere Mechanics in cTn and Tm DCM Mutants—Genotype to Cellular Phenotype

Frontiers in Physiology

S. Dewan, K. J. McCabe, M. Regnier, A. D. McCulloch and S. Lindert

Molecular Effects of cTnC DCM Mutations on Calcium Sensitivity and Myofilament Activation—An Integrated Multiscale Modeling Study

The Journal of Physical Chemistry B

Y. Aboelkassem, J. Bonilla, K. J. McCabe and S. Campbell

Contributions of Ca 2+ -Independent Thin Filament Activation to Cardiac Muscle Function

Biophysical Journal