
- kimberly@simula.no
Publications
2025
Journal Articles
M. V. Hernández, K. J. McCabe and P. Rangamani
Synaptic cleft geometry modulates NMDAR opening probability by tuning neurotransmitter residence time
Biophysical Journal
2024
Journal Articles
K. J. McCabe, N. Forsch, A. G. Edwards and M. Maleckar
Summer School in Computational Physiology: A Collaborative Course in Modeling Excitable Tissues
The Biophysicist
A. Teitgen, M. T. Hock, K. J. McCabe, M. C. Childers, G. Huber, B. Marzban, D. Beard, A. J. McCammon, M. Regnier and A. D. McCulloch
Multiscale modeling shows how 2’-deoxy-ATP rescues ventricular function in heart failure
PNAS
Edited books
Computational Physiology: Simula Summer School 2023 − Student Reports
2023
Journal Articles
M. T. Hock, A. Teitgen, K. J. McCabe, S. P. Hirakis, G. Huber, M. Regnier, R. E. Amaro, A. J. McCammon and A. D. McCulloch
Multiscale computational modeling of the effects of 2’-deoxy-ATP on cardiac muscle calcium handling
Journal of Applied Physics
Edited books
Computational Physiology: Simula Summer School 2022− Student Reports
2022
Journal Articles
M. H. Mesa, J. van den Brink, W. E. Louch, K. J. McCabe and P. Rangamani
Nanoscale organization of ryanodine receptor distribution and phosphorylation pattern determines the dynamics of calcium sparks
PLOS Computational Biology
Edited books
Computational Physiology: Simula Summer School 2021 − Student Reports
2021
Journal Articles
K. J. McCabe and P. Rangamani
Computational modeling approaches to cAMP/PKA signaling in cardiomyocytes
Journal of Molecular and Cellular Cardiology
2020
Journal Articles
K. J. McCabe, Y. Aboelkassem, A. Teitgen, G. Huber, A. J. McCammon, M. Regnier and A. D. McCulloch
Predicting the effects of dATP on cardiac contraction using multiscale modeling of the sarcomere
Archives of Biochemistry and Biophysics
Talks, contributed
K. J. McCabe, Y. Aboelkassem, A. Teitgen, M. Regnier and A. D. McCulloch
Multiscale modelling determines mechanisms of action for 2'-deoxy-ATP, a myosin activating therapeutic for heart failure
VPH 2020, Paris, France (Virtual)
2019
Journal Articles
Y. Aboelkassem, K. J. McCabe, G. Huber, M. Regnier, A. J. McCammon and A. D. McCulloch
A Stochastic Multiscale Model of Cardiac Thin Filament Activation Using Brownian-Langevin Dynamics
Biophysical Journal
Y. Aboelkassem, J. D. Powers, K. J. McCabe and A. D. McCulloch
Multiscale Models of Cardiac Muscle Biophysics and Tissue Remodeling in Hypertrophic Cardiomyopathies
Current Opinion in Biomedical Engineering
J. D. Powers, C. Yuan, K. J. McCabe, J. D. Murray, M. C. Childers, G. Flint, F. Moussavi-Harami, S. Mohran, R. Castillo, C. Zuzek, W. Ma, V. Daggett, A. D. McCulloch, T. C. Irving and M. Regnier
Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin
Proceedings of the National Academy of Sciences
2018
Posters
Y. Aboelkassem, K. J. McCabe, G. Huber, J. Sundnes and A. D. McCulloch
Turning the Azimuthal Motions of Adjacent Tropomyosins into a Coupled N-body Problem in a Brownian Model of Cardiac Thin Filament Activation
Biophysical Journal
K. J. McCabe, Y. Aboelkassem, S. Dewan, M. Regnier and A. D. McCulloch
A Markov State Model of the Sarcomere to Explain the Effects of dATP on Cardiac Contraction
2017
Journal Articles
S. Dewan, K. J. McCabe, M. Regnier and A. D. McCulloch
Insights and Challenges of Multi-Scale Modeling of Sarcomere Mechanics in cTn and Tm DCM Mutants—Genotype to Cellular Phenotype
Frontiers in Physiology
2016
Journal Articles
S. Dewan, K. J. McCabe, M. Regnier, A. D. McCulloch and S. Lindert
Molecular Effects of cTnC DCM Mutations on Calcium Sensitivity and Myofilament Activation—An Integrated Multiscale Modeling Study
The Journal of Physical Chemistry B
2015
Journal Articles
Y. Aboelkassem, J. Bonilla, K. J. McCabe and S. Campbell
Contributions of Ca 2+ -Independent Thin Filament Activation to Cardiac Muscle Function
Biophysical Journal