My scientific work is focused on waste clearance mechanisms from the brain. I have mainly focused on mathematical models of basic physical processes like fluid flow, diffusion and convection of molecules, and have used complex geometries (e.g. the brain) for these models. My main contributions to the field can be grouped in two categories: 1) Computational and mathematical models to explain experimental observations and link them to current theories on fluid flow in the central nervous system and 2) Computational models to predict fluid flow and waste clearance from the brain based on limited experimental data.