AuthorsW. E. Louch, J. Koivumäki and P. Tavi
TitleCalcium Signaling in Developing Cardiomyocytes: Implications for Model Systems and Disease
AfilliationScientific Computing, ,
Project(s)Center for Biomedical Computing (SFF)
StatusPublished
Publication TypeJournal Article
Year of Publication2015
JournalThe Journal of Physiology
Volume593
Issue5
Pagination1047-1063
Date Published03/2015
PublisherJohn Wiley and Sons
Abstract

Adult cardiomyocytes exhibit complex Ca2+ homeostasis, enabling tight control of contraction and relaxation. This intricate regulatory system develops gradually, with progressive maturation of specialized structures and increasing capacity of Ca2+ sources and sinks. In this review, we outline current understanding of these developmental processes, and draw parallels to pathophysiological conditions where cardiomyocytes exhibit a striking regression to an immature state of Ca2+ homeostasis. We further highlight the importance of understanding developmental physiology when employing immature cardiomyocyte models such as neonatal cell culture and stem cells.

URLhttp://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2014.274712/abstract
DOI10.1113/jphysiol.2014.274712
Citation KeySimula.simula.3028