|Authors||J. Lumens, K. Vernooy, J. H. Omens, L. J. Mulligan, T. Delhaas, T. Arts, A. D. McCulloch and F. W. Prinzen|
|Title||Cardiac Resynchronization: Insight From Experimental and Computational Models|
|Afilliation||Center for Biomedical Computing (SFF), Scientific Computing|
|Project(s)||Center for Biomedical Computing (SFF)|
|Publication Type||Journal Article|
|Year of Publication||2008|
|Journal||Progress in Biophysics and Molecular Biology|
Cardiac resynchronization therapy (CRT) is a promising therapy for heart failure patients with a conduction disturbance, such as left bundle branch block. The aim of CRT is to resynchronize contraction between and within ventricles. However, about 30% of patients do not respond to this therapy. Therefore, a better understanding is needed for the relation between electrical and mechanical activation. In this paper, we focus on to what extent animal experiments and mathematical models can help in order to understand the pathophysiology of asynchrony to further improve CRT.