|Authors||E. M. Arruda, S. Calve, K. Garikipati, K. Grosh and H. Narayanan|
|Editors||G. A. Holzapfel and R. W. Ogden|
|Title||Characterization and Modeling of Growth and Remodeling in Tendon and Soft Tissue Constructs|
|Publication Type||Book Chapter|
|Year of Publication||2006|
|Book Title||Mechanics of Biological Tissue|
Separate theories of growth and remodeling have been outlined to illustrate that remodeling may occur at constant mass and is a configurational change whereas growth involves a change in the concentration of species. Engineered tendon constructs were generated for growth and remodeling studies. The constructs demonstrate mechanically responsive cells, grow and remain viable in culture for several weeks. They are excellent in vitro models for growth studies.