AuthorsV. Vinje, B. Zapf, G. Ringstad, P. K. Eide, M. E. Rognes and K. Mardal
TitleHuman brain solute transport quantified by glymphatic MRI-informed biophysics during sleep and sleep deprivation
AfilliationScientific Computing
Project(s)Department of Numerical Analysis and Scientific Computing
Publication TypeJournal Article
Year of Publication2023

Human brain homeostasis requires carefully regulated transport of nutrients and waste, but its governing mechanisms are hard to quantify. By combining multi-modal gMRI data over 48 hours with high-fidelity inverse computational modelling, we here identify several potential transport mechanisms that best explain the clinical observations. Our findings support the combined roles of local, vascular and glymphatic-type clearance pathways within human brain tissue with tissue flow velocities on the order of $\mu$m/min, local clearance rates at the order of 10**(-3)/min, and enhanced diffusion by a factor 3.5, in sleeping and sleep-deprived subjects. Reduced advection fully explains reduced tracer clearance after sleep-deprivation, supporting the role of sleep and sleep deprivation on human brain clearance.

Citation Key43096

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