AuthorsH. Narayanan, E. M. Arruda, K. Grosh and K. Garikipati
TitleThe Micromechanics of Fluid-Solid Interactions During Growth in Porous Soft Biological Tissue
Afilliation, Scientific Computing
Project(s)Center for Biomedical Computing (SFF)
StatusPublished
Publication TypeJournal Article
Year of Publication2009
JournalBiomechanics and Modeling in Mechanobiology
Volume8
Number3
Pagination167-181
Abstract

In this paper, we address some modelling issues related to biological growth. Our treatment is based on a formulation for growth that was proposed within the context of mixture theory (J Mech Phys Solids 52:1595-1625, 2004). We aim to make this treatment more appropriate for the physics of porous soft tissues, paying particular attention to the nature of fluid transport, and mechanics of fluid and solid phases. The interactions between transport and mechanics have significant implications for growth and swelling. We also reformulate the governing differential equations for reaction-transport of solutes to represent the incompressibility constraint on the fluid phase of the tissue. This revision enables a straightforward implementation of numerical stabilisation for the advection-dominated limit of these equations. A finite element implementation with operator splitting is used to solve the coupled, non-linear partial differential equations that arise from the theory. We carry out a numerical and analytic study of the convergence of the operator splitting scheme subject to strain- and stress-homogenisation of the mechanics of fluid-solid interactions. A few computations are presented to demonstrate aspects of the physical mechanisms, and the numerical performance of the formulation.

DOI10.1007/s10237-008-0126-1
Citation KeySimula.SC.352