|Authors||V. Vinje, G. Ringstad, M. E. Rognes, P. K. Eide and K. Mardal|
|Title||Respiratory influence on intracranial pressure gradients and aqueductal flow in normal pressure hydrocephalus|
|Project(s)||Waterscape: The Numerical Waterscape of the Brain|
|Year of Publication||2018|
|Place Published||Dublin, Ireland|
|Type of Work||Poster Presentation at World Congress of Biomechanics|
Phase contrast MRI does not take into account the role of respiration on cerebrospinal fluid (CSF) flow. We used in vivo pressure measurements from two locations in the intracranial space to calculate a pulsatile pressure gradient. This pressure data was used as input to an idealized model of the aqueduct to calculate CSF flow. We found the cardiac and respiratory cycle to contribute equally to CSF flow. The total flow volume was dominated by respiration, and all subjects showed variability in pressure gradients over time resulting also in variability in CSF flow.