AuthorsV. Vinje, G. Ringstad, M. E. Rognes, P. K. Eide and K. Mardal
TitleRespiratory influence on intracranial pressure gradients and aqueductal flow in normal pressure hydrocephalus
AfilliationScientific Computing
Project(s)Waterscape: The Numerical Waterscape of the Brain
Publication TypePoster
Year of Publication2018
Date Published07/2018
Place PublishedDublin, Ireland
Type of WorkPoster Presentation at World Congress of Biomechanics

Phase contrast MRI does not take into account the role of respiration on cerebrospinal fluid (CSF) flow. We used in vivo pressure measurements from two locations in the intracranial space to calculate a pulsatile pressure gradient. This pressure data was used as input to an idealized model of the aqueduct to calculate CSF flow. We found the cardiac and respiratory cycle to contribute equally to CSF flow. The total flow volume was dominated by respiration, and all subjects showed variability in pressure gradients over time resulting also in variability in CSF flow.

Citation Key26046