AuthorsT. Stöber, A. Lehr, T. Hafting, A. Kumar and M. Fyhn
TitleSelective neuromodulation and mutual inhibition within the CA3-CA2 system can prioritize sequences for replay
AfilliationScientific Computing
Project(s)Department of Numerical Analysis and Scientific Computing
StatusPublished
Publication TypeJournal Article
Year of Publication2020
JournalHippocampus
Volume30
Issue11
Pagination1228-1238
Publisher John Wiley & Sons
KeywordsCA2, CA3, consolidation, hippocampus, sequence prioritization
Abstract

To make optimal use of previous experiences, important neural activity sequences must be prioritized during hippocampal replay. Integrating insights about the interplay between CA3 and CA2, we propose a conceptual framework that allows the two regions to control which sequences are reactivated. We suggest that neuromodulatory‐gated plasticity and mutual inhibition enable discrete assembly sequences in both regions to support each other while suppressing competing sequences. This perspective provides a coherent interpretation for a variety of seemingly disconnected functional properties of CA2 and paves the way for a more general understanding of CA2.

DOI10.1002/hipo.23256
Citation Key27689