In this study we performed diffusion simulations using input data from an experimental study by Eide et al. on sleep deprivation. Patient specific input data included detailed MR-images used to construct geometries, diffusion tensor images to determine the diffusion tensor and concentration data on the brain surface to determine the correct boundary condition for the simulation. We then compared our simulation results to the experimentally observed data to observe differences in transport into the brain. Our results show differences between experimental data compared to diffusion, however the difference between sleep and sleep deprived individuals was surprisingly small compared to previously published data on animals.