Authors | Y. Yao, A. Zia, R. S. Neumann, M. Pavlovic, G. Balaban, K. E. A. Lundin, G. K. Sandve and S. Qiao |
Title | T cell receptor repertoire as a potential diagnostic marker for celiac disease |
Afilliation | Scientific Computing |
Project(s) | No Simula project |
Status | Published |
Publication Type | Journal Article |
Year of Publication | 2021 |
Journal | Clinical Immunology |
Volume | 222 |
Date Published | 01/2021 |
Publisher | Elsevier |
Abstract | An individual's T cell repertoire is skewed towards some specificities as a result of past antigen exposure and subsequent clonal expansion. Identifying T cell receptor signatures associated with a disease is challenging due to the overall complexity of antigens and polymorphic HLA allotypes. In celiac disease, the antigen epitopes are well characterised and the specific HLA-DQ2-restricted T-cell repertoire associated with the disease has been explored in depth. By investigating T cell receptor repertoires of unsorted lamina propria T cells from 15 individuals, we provide the first proof-of-concept study showing that it could be possible to infer disease state by matching against a priori known disease-associated T cell receptor sequences. |
Citation Key | 28044 |