AuthorsH. Osnes and J. Sundnes
TitleUncertainty Analysis of Ventricular Mechanics Using the Probabilistic Collocation Method
Afilliation, Scientific Computing, Scientific Computing
Project(s)Center for Biomedical Computing (SFF)
Publication TypeJournal Article
Year of Publication2012
JournalIEEE Transactions on Biomedical Engineering
Date PublishedAugust

Uncertainty and variability in material parameters are fundamental challenges in computational biomechanics. Analyzing and quantifying the resulting uncertainty in computed results with parameter sweeps or Monte Carlo methods has become very computationally demanding. In this paper we consider a stochastic method named the probabilistic collocation method, and investigate its applicability for uncertainty analysis in computing the passive mechanical behaviour of the left ventricle. Specifically, we study the effect of uncertainties in material input parameters upon response properties such as the increase in cavity volume, the elongation of the ventricle, the increase in inner radius, the decrease in wall thickness and the rotation at apex. The numerical simulations conducted herein indicate that the method is well suited for the problem of consideration, and is far more efficient than the Monte Carlo simulation method for obtaining a detailed uncertainty quantification. The numerical experiments also give interesting indications on which material parameters are most critical for accurately determining various global responses.

Citation Keyheartmech-uncertainty