|Authors||A. K. Diem|
|Title||Using porous media to bridge multiple scales and guide clinical experiments|
|Project(s)||No Simula project|
|Publication Type||Talks, invited|
|Year of Publication||2018|
|Location of Talk||SIAM Life Sciences, Minneapolis, MN, USA|
Modelling biological systems with the purpose of guiding and ultimately reducing clinical experiments brings a number of challenges. Crucially, biological flow processes, such as cerebral fluid dynamics, occur over multiple scales. In this talk I present the development of a model of interstitial fluid dynamics within the very narrow (~200 nm) basement membranes (BM) inside the wall of cerebral arteries coupled with blood flow in the cerebral vasculature (up to mm diameter). This process is termed intramural periarterial drainage (IPAD) and experiments have shown that it constitutes a crucial part of the brain's waste disposal system. The model uses Darcy's law to represent the BM's complex protein mesh and exploits the permeability parameter KK to develop a macroscopic representation of nano-scale physiological features such as a valve mechanism. First, the model was used to show that, although regarded as the most likely candidate by clinicians, arterial pulsations are not a suitable driving mechanism for IPAD. It was further applied to develop an alternative hypothesis that aligns better with clinical observations, demonstrating the usefulness of such models to evaluate and refine clinical hypotheses.