Andy Edwards
Chief Research Scientist
- Department
- Computational Physiology
- Organisation
- Simula Research Laboratory
- andy@simula.no
Publications
2024
Journal Articles
K. J. McCabe, N. Forsch, A. G. Edwards and M. Maleckar
Summer School in Computational Physiology: A Collaborative Course in Modeling Excitable Tissues
The Biophysicist
2023
Journal Articles
A. G. Edwards, A. D. McCulloch, A. T. Quinn, J. Sundnes, S. Wall and V. Timmermann
An In-Silico Study on Integrated Mechanisms of Mechano-Electric Coupling in Ischemic Arrhythmogenesis
BioarXiv
I. van Herck, V. Seutin, B. H. Bentzen, N. Marrion and A. G. Edwards
Gating kinetics and pharmacological properties of small-conductance Ca2+-activated potassium channels
Biophysical Journal
Book Chapters
A. G. Edwards, I. Goswami, G. Neiman, J. Shuttleworth and M. Bloothooft
Recapitulating Functional Heterogeneity in Electrophysiologically Active Tissues
Computational Physiology: Simula Summer School 2022 - Student Reports
2022
Journal Articles
E. Grandi, A. G. Edwards, W. E. Louch, D. Sato, C. E. R. Smith, S. Morotti, H. Ni and X. Zhang
Mechanisms of spontaneous Ca2+ release-mediated arrhythmia in a novel 3D human atrial myocyte model: I. Transverse-axial tubule variation
The Journal of Physiology
V. Charwat, B. Charrez, B. A. Siemons, H. Finsberg, K. H. Jæger, A. G. Edwards, N. Huebsch, S. Wall, E. Miller, A. Tveito and K. E. Healy
Validating the Arrhythmogenic Potential of High-, Intermediate-, and Low-Risk Drugs in a Human-Induced Pluripotent Stem Cell-Derived Cardiac Microphysiological System
ACS Pharmacology & Translational Science
W. E. Louch, H. Perdreau-Dahl and A. G. Edwards
Image-Driven Modeling of Nanoscopic Cardiac Function: Where Have We Come From, and Where Are We Going?
Frontiers in Physiology
N. Huebsch, B. Charrez, G. Neiman, B. Siemons, S. C. Boggess, S. Wall, V. Charwat, K. H. Jæger, D. Cleres, Å. Telle, F. T. Lee-Montiel, N. C. Jeffreys, N. Deveshwar, A. G. Edwards, J. Serrano, M. Snuderl, A. Stahl, A. Tveito, E. W. Miller and K. E. Healy
Metabolically driven maturation of human-induced-pluripotent-stem-cell-derived cardiac microtissues on microfluidic chips
Nature Biomedical Engineering
X. Shen, J. van den Brink, A. Bergan-Dahl, T. R. Kolstad, E. S. Norden, Y. Hou, M. Laasmaa, Y. Aguilar-Sanchez, A. P. Quick, E. K. S. Espe, I. Sjaastad, X. H. Wehrens, A. G. Edwards, C. Soeller and W. E. Louch
Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes
eLife
K. H. Jæger, A. G. Edwards, W. R. Giles and A. Tveito
Arrhythmogenic influence of mutations in a myocyte‑based computational model of the pulmonary vein sleeve
Nature Scientific Reports
2021
Journal Articles
A. G. Edwards, H. Mørk, M. K. Stokke, D. B. Lipsett, I. Sjaastad, S. Richard, O. M. Sejersted and W. E. Louch
Sarcoplasmic Reticulum Calcium Release Is Required for Arrhythmogenesis in the MouseData_Sheet_1.pdf
Frontiers in Physiology
A. F. Iseppe, H. Ni, S. Zhu, X. Zhang, R. Coppini, P. Yang, U. Srivatsa, C. E. Clancy, A. G. Edwards, S. Morotti and E. Grandi
Sex‐Specific Classification of Drug‐Induced Torsade de Pointes Susceptibility Using Cardiac Simulations and Machine Learning
Clinical Pharmacology & Therapeutics
K. H. Jæger, A. G. Edwards, W. R. Giles and A. Tveito
From Millimeters to Micrometers; Re-introducing Myocytes in Models of Cardiac Electrophysiology
Frontiers in Physiology
K. H. Jæger, A. G. Edwards, W. R. Giles and A. Tveito
A computational method for identifying an optimal combination of existing drugs to repair the action potentials of SQT1 ventricular myocytes
PLoS Computational Biology
B. Charrez, V. Charwat, B. Siemons, H. Finsberg, E. Miller, A. G. Edwards and K. E. Healy
In vitro safety “clinical trial” of the cardiac liability of drug polytherapy
Clinical and Translational Science
B. Charrez, V. Charwat, B. Siemons, I. Goswami, C. Sakolish, Y. Luo, H. Finsberg, A. G. Edwards, E. Miller, I. Rusyn and K. Healy
Heart Muscle Microphysiological System for Cardiac Liability Prediction of Repurposed COVID-19 Therapeutics
Frontiers in Pharmacology
Book Chapters
A. G. Edwards, J. van den Brink and A. D. McCulloch
Calcium Signaling in Cardiomyocyte Models With Realistic Geometries
Zipes and Jalife's Cardiac Electrophysiology: From Cell to Bedside
2020
Journal Articles
B. Charrez, V. Charwat, B. Siemons, H. Finsberg, E. Miller, A. G. Edwards and K. E. Healy
In Vitro Safety “Clinical Trial” of the Cardiac Liability of Hydroxychloroquine and Azithromycin as COVID19 Polytherapy
Clinical Pharmacology & Therapeutics
T. Mäki-Marttunen, N. Iannella, A. G. Edwards, G. T. Einevoll and K. T. Blackwell
A unified computational model for cortical post-synaptic plasticity
eLife
V. Timmermann, A. T. Quinn, J. Sundnes, S. Wall, A. D. McCulloch and A. G. Edwards
A computational study on integrated mechanisms of mechano-electric feedback in ischemic arrhythmogenesis
SAGE
Posters
X. Shen, T. R. Kolstad, J. van den Brink, M. Frisk, Y. Hou, E. Norden, A. G. Edwards, I. Sjaastad, C. Soeller and W. E. Louch
3D Dstorm Imaging Reveals Camkii-Dependent Dispersal of Ryanodine Receptor Clusters in Failing Rat Cardiomyocytes
Biophysical Journal
2019
Journal Articles
V. Timmermann, A. G. Edwards, S. Wall, J. Sundnes and A. D. McCulloch
Arrhythmogenic current generation by myofilament-triggered Ca2+ release and sarcomere heterogeneity
Biophysical Journal
T. Mäki-Marttunen, T. Kaufmann, T. Elvs\aashagen, A. Devor, S. Djurovic, L. T. Westlye, M. Linne, M. Rietschel, D. Schubert, S. Borgwardt, M. Efrim-Budisteanu, F. Bettella, G. Halnes, E. Hagen, S. Næss, T. Ness, T. Moberget, C. Metzner, A. G. Edwards, M. Fyhn, A. M. Dale, G. T. Einevoll and O. A. Andreassen
Biophysical Psychiatry—How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders
Frontiers in psychiatry
K. H. Jæger, A. G. Edwards, A. D. McCulloch and A. Tveito
Properties of cardiac conduction in a cell-based computational model
PLoS Computational Biology
X. Shen, J. van den Brink, Y. Hou, D. Colli, C. Le, T. R. Kolstad, N. MacQuaide, C. R. Carlson, P. M. Kekenes-Huskey, A. G. Edwards, C. Soeller and W. E. Louch
3D dSTORM imaging reveals novel detail of ryanodine receptor localization in rat cardiac myocytes
The Journal of Physiology
Talks, contributed
V. Timmermann, J. Sundnes, S. Wall, A. D. McCulloch and A. G. Edwards
A one-dimensional computational study of mechano-electric feedback and arrhythmogenic current generation
Gordon Research Conference "Cardiac Arrhythmia Mechanisms", Barga, Italy
2018
Journal Articles
I. van Herck, B. H. Bentzen, V. Seutin, H. Arevalo, M. Maleckar, N. Marrion and A. G. Edwards
Model development of sk channel gating incorporating calcium sensitivity and drug interaction
Biophysical Journal
T. Mäki-Marttunen, F. Krull, F. Bettella, E. Hagen, S. Næss, T. Ness, T. Moberget, T. Elvs\aashagen, C. Metzner, A. Devor, A. G. Edwards, M. Fyhn, S. Djurovic, A. M. Dale, O. A. Andreassen and G. T. Einevoll
Alterations in Schizophrenia-Associated Genes Can Lead to Increased Power in Delta Oscillations
Cerebral Cortex
N. Huebsch, B. Charrez, B. Siemons, S. C. Boggess, S. Wall, V. Charwat, K. Jaeger, F. L. T. Montiel, N. C. Jeffreys, N. Deveshwar, A. G. Edwards, J. Serrano, M. Snuderl, A. Stahl, A. Tveito, E. W. Miller and K. E. Healy
Metabolically-Driven Maturation of hiPSC-Cell Derived Heart-on-a-Chip
{bioRxiv
T. R. Kolstad, J. van den Brink, N. MacQuaide, P. K. Lunde, M. Frisk, J. M. Aronsen, E. S. Norden, A. Cataliotti, I. Sjaastad, O. M. Sejersted, A. G. Edwards, G. T. Lines and W. E. Louch
Ryanodine Receptor Dispersion Disrupts Ca2+-Release in Failing Cardiac Myocytes
eLife
M. Vagos, I. G. M. van Herck, J. Sundnes, H. Arevalo, A. G. Edwards and J. Koivumäki
Computational Modeling of Electrophysiology and Pharmacotherapy of Atrial Fibrillation: Recent Advances and Future Challenges
Frontiers in Physiology
A. Tveito, K. H. Jæger, N. Huebsch, B. Charrez, A. G. Edwards, S. Wall and K. E. Healy
Inversion and computational maturation of drug response using human stem cell derived cardiomyocytes in microphysiological systems
Nature Scientific Reports
Posters
I. G. M. van Herck, B. H. Bentzen, V. Seutin, J. Koivumäki, M. Maleckar, N. Marrion and A. G. Edwards
In silico Model of Gating Kinetics, Temperature Dependence and Calcium Sensitivity of the SK Channel
I. G. M. van Herck, B. H. Bentzen, V. Seutin, H. Arevalo, M. Maleckar, N. Marrion and A. G. Edwards
Model development of SK channel gating incorporating calcium sensitivity and drug interaction
Talks, contributed
V. Timmermann, J. Sundnes, S. Wall, A. D. McCulloch and A. G. Edwards
A computational study of the contribution of mechano-electric feedback to arrhythmogenic current generation
Berlin, Germany
S. Wall, A. Tveito, K. H. Jæger, A. G. Edwards, K. Healy, N. Huebsch and B. Charrez
In Silico Modeling of Cardiac Microphysiological Systems for Evaluating Drug Side Effects
Heart By Numbers Conference, Berlin, Germany
2017
Journal Articles
V. Timmermann, L. A. Dejgaard, K. H. Haugaa, A. G. Edwards, A. D. McCulloch, J. Sundnes and S. Wall
An integrative appraisal of mechano-electric feedback mechanisms in the heart
Progress in biophysics and molecular biology
M. Maleckar, A. G. Edwards, W. E. Louch and G. T. Lines
Studying dyadic structure–function relationships: a review of current modeling approaches and new insights into ca2+ (mis) handling
Clinical Medicine Insights: Cardiology
V. Timmermann, L. A. Dejgaard, K. H. Haugaa, A. G. Edwards, J. Sundnes, A. D. McCulloch and S. Wall
An integrative appraisal of mechano-electric feedback mechanisms in the heart
Progress in biophysics and molecular biology
A. G. Edwards and W. E. Louch
Species-Dependent Mechanisms of Cardiac Arrhythmia: A Cellular Focus
Clinical Medicine Insights: Cardiology
T. Mäki-Marttunen, G. T. Lines, A. G. Edwards, A. Tveito, A. M. Dale, G. T. Einevoll and O. A. Andreassen
Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling
Translational Psychiatry
A. Tveito, K. H. Jæger, G. T. Lines, Ł. Paszkowski, J. Sundnes, A. G. Edwards, T. Mäki-Marttunen, G. Halnes and G. T. Einevoll
An Evaluation of the Accuracy of Classical Models for Computing the Membrane Potential and Extracellular Potential for Neurons
Frontiers in Computational Neuroscience
M. Maleckar, A. G. Edwards, W. Louch and G. T. Lines
Studying dyadic structure-function relationships: a review of current modeling approaches and new insights into Ca2+ (mis)handling
Clinical Medicine Insights: Cardiology
Posters
I. G. M. van Herck, R. S. Vicens, H. Arevalo, J. Koivumäki, B. H. Bentzen and A. G. Edwards
Small conductance calcium activated potassium channel: pharmacology and binding scheme for in silico model
V. Timmermann, L. A. Dejgaard, A. D. McCulloch, K. H. Haugaa, A. G. Edwards and S. Wall
Role of Electromechanical Feedback in Stretch Induced Arrhythmias : From Single Myocyte to Multicellular Level
V. Timmermann, S. Wall, J. Sundnes, T. A. Quinn and A. G. Edwards
Integrated Mechanisms of Mechano-Electric Feedback in Ischemic Arrhythmogenesis
Talks, contributed
V. Timmermann, A. G. Edwards, J. Sundnes, A. D. McCulloch, S. Wall and T. A. Quinn
Integrated Mechanisms of Mechano-Electric feedback in Ischemic Arrhythmogenesis
Bergen, Norway
2016
Journal Articles
A. Tveito, G. T. Lines, A. G. Edwards and A. D. McCulloch
Computing rates of Markov models of voltage-gated ion channels by inverting partial differential equations governing the probability density functions of the conducting and non-conducting states
Mathematical Biosciences
Posters
V. Timmermann, A. G. Edwards, J. Sundnes, A. D. McCulloch and S. Wall
Role of Electromechanical Feedback in Mitral Valve Prolapse Arrhythmia
2015
Posters
S. Morotti, A. D. McCulloch, D. M. Bers, A. G. Edwards and E. Grandi
Ranolazine Prevents Phase-3 Early Afterdepolarizations in Human Atrial Myocytes by Inhibiting Na Current Non-Equilibrium Reactivation
Biophysical Society annual meeting