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V. Charwat, B. Charrez, B. A. Siemons, H. Finsberg, K. H. Jæger, A. G. Edwards, N. Huebsch, S. Wall, E. Miller, A. Tveito et al.

Validating the Arrhythmogenic Potential of High-, Intermediate-, and Low-Risk Drugs in a Human-Induced Pluripotent Stem Cell-Derived Cardiac Microphysiological System

ACS Pharmacology & Translational Science 5, no. 8 (2022): 652-667.
Journal Article
2022
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X. Zhang, C. E. R. Smith, S. Morotti, A. G. Edwards, D. Sato, W. E. Louch, H. Ni and E. Grandi

Mechanisms of spontaneous Ca<sup>2+</sup> release‐mediated arrhythmia in a novel 3D human atrial myocyte model: II Ca<sup>2+</sup>‐handling protein variation

The Journal of Physiology 116 (2022).
Journal Article
2022
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X. Zhang, H. Ni, S. Morotti, C. E. R. Smith, D. Sato, W. E. Louch, A. G. Edwards and E. Grandi

Mechanisms of spontaneous Ca <sup>2+</sup> release‐mediated arrhythmia in a novel 3D human atrial myocyte model: I. Transverse‐axial tubule variation

The Journal of Physiology (2022).
Journal Article
2022
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W. E. Louch, H. Perdreau-Dahl and A. G. Edwards

Image-Driven Modeling of Nanoscopic Cardiac Function: Where Have We Come From, and Where Are We Going?

Frontiers in Physiology 13 (2022).
Journal Article
2022
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18 June 2019
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Viviane Timmermann successfully defended her PhD

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2022

Journal articles

V. Charwat, B. Charrez, B. A. Siemons, H. Finsberg, K. H. Jæger, A. G. Edwards, N. Huebsch, S. Wall, E. Miller, A. Tveito et al.

Validating the Arrhythmogenic Potential of High-, Intermediate-, and Low-Risk Drugs in a Human-Induced Pluripotent Stem Cell-Derived Cardiac Microphysiological System

ACS Pharmacology & Translational Science 5, no. 8 (2022): 652-667.
Status: Published
N. Huebsch, B. Charrez, G. Neiman, B. Siemons, S. C. Boggess, S. Wall, V. Charwat, K. H. Jæger, D. Cleres, Å. Telle et al.

Metabolically driven maturation of human-induced-pluripotent-stem-cell-derived cardiac microtissues on microfluidic chips

Nature Biomedical Engineering 6, no. 4 (2022): 372-388.
Status: Published
K. H. Jæger, A. G. Edwards, W. R. Giles and A. Tveito

Arrhythmogenic influence of mutations in a myocyte‑based computational model of the pulmonary vein sleeve

Nature Scientific Reports 12 (2022): 7040.
Status: Published
W. E. Louch, H. Perdreau-Dahl and A. G. Edwards

Image-Driven Modeling of Nanoscopic Cardiac Function: Where Have We Come From, and Where Are We Going?

Frontiers in Physiology 13 (2022).
Status: Published
X. Shen, J. van den Brink, A. Bergan-Dahl, T. R. Kolstad, E. S. Norden, Y. Hou, M. Laasmaa, Y. Aguilar-Sanchez, A. P. Quick, E. K. S. Espe et al.

Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes

eLife 11 (2022).
Status: Published
X. Zhang, H. Ni, S. Morotti, C. E. R. Smith, D. Sato, W. E. Louch, A. G. Edwards and E. Grandi

Mechanisms of spontaneous Ca <sup>2+</sup> release‐mediated arrhythmia in a novel 3D human atrial myocyte model: I. Transverse‐axial tubule variation

The Journal of Physiology (2022).
Status: Published
X. Zhang, C. E. R. Smith, S. Morotti, A. G. Edwards, D. Sato, W. E. Louch, H. Ni and E. Grandi

Mechanisms of spontaneous Ca<sup>2+</sup> release‐mediated arrhythmia in a novel 3D human atrial myocyte model: II Ca<sup>2+</sup>‐handling protein variation

The Journal of Physiology 116 (2022).
Status: Published
2021

Journal articles

B. Charrez, V. Charwat, B. Siemons, H. Finsberg, E. Miller, A. G. Edwards and K. E. Healy

In vitro safety “clinical trial” of the cardiac liability of drug polytherapy

Clinical and Translational Science 14, no. 3 (2021): 1155-1165.
Status: Published
B. Charrez, V. Charwat, B. Siemons, I. Goswami, C. Sakolish, Y. Luo, H. Finsberg, A. G. Edwards, E. Miller, I. Rusyn et al.

Heart Muscle Microphysiological System for Cardiac Liability Prediction of Repurposed COVID-19 Therapeutics

Frontiers in Pharmacology 12 (2021): 684252.
Status: Published
A. G. Edwards, H. Mørk, M. K. Stokke, D. B. Lipsett, I. Sjaastad, S. Richard, O. M. Sejersted and W. E. Louch

Sarcoplasmic Reticulum Calcium Release Is Required for Arrhythmogenesis in the MouseData_Sheet_1.pdf

Frontiers in Physiology 129247113307196118101757330290951073619410426311810310255549995881112965921565931388107972921061031069987209102119109419102782 (2021).
Status: Published