Andy Edwards

L. Lunsonga, A. G. Edwards and P. Light

The Sodium/Glucose Cotransporter 2 Inhibitor Empagliflozin Inhibits Long QT 3 Late Sodium Currents in a Mutation Specific Manner

Journal of Molecular and Cellular Cardiology

K. J. McCabe, N. Forsch, A. G. Edwards and M. Maleckar

Summer School in Computational Physiology: A Collaborative Course in Modeling Excitable Tissues

The Biophysicist

R. Shetty, R. Singh-Agarwal, S. Meier, C. Goetz and A. G. Edwards

Reconstruction of a Pancreatic Beta Cell Network From Heterogeneous Functional Measurements

Computational Physiology: Simula Summer School 2023 − Student Reports

A. G. Edwards, A. D. McCulloch, A. T. Quinn, J. Sundnes, S. Wall and V. Timmermann

An In-Silico Study on Integrated Mechanisms of Mechano-Electric Coupling in Ischemic Arrhythmogenesis

BioarXiv

I. van Herck, V. Seutin, B. H. Bentzen, N. Marrion and A. G. Edwards

Gating kinetics and pharmacological properties of small-conductance Ca2+-activated potassium channels

Biophysical Journal

A. G. Edwards, I. Goswami, G. Neiman, J. Shuttleworth and M. Bloothooft

Recapitulating Functional Heterogeneity in Electrophysiologically Active Tissues

Computational Physiology: Simula Summer School 2022 - Student Reports

E. Grandi, A. G. Edwards, W. E. Louch, D. Sato, C. E. R. Smith, S. Morotti, H. Ni and X. Zhang

Mechanisms of spontaneous Ca2+ release-mediated arrhythmia in a novel 3D human atrial myocyte model: I. Transverse-axial tubule variation

The Journal of Physiology

V. Charwat, B. Charrez, B. A. Siemons, H. Finsberg, K. H. Jæger, A. G. Edwards, N. Huebsch, S. Wall, E. Miller, A. Tveito and K. E. Healy

Validating the Arrhythmogenic Potential of High-, Intermediate-, and Low-Risk Drugs in a Human-Induced Pluripotent Stem Cell-Derived Cardiac Microphysiological System

ACS Pharmacology & Translational Science

W. E. Louch, H. Perdreau-Dahl and A. G. Edwards

Image-Driven Modeling of Nanoscopic Cardiac Function: Where Have We Come From, and Where Are We Going?

Frontiers in Physiology

N. Huebsch, B. Charrez, G. Neiman, B. Siemons, S. C. Boggess, S. Wall, V. Charwat, K. H. Jæger, D. Cleres, Å. Telle, F. T. Lee-Montiel, N. C. Jeffreys, N. Deveshwar, A. G. Edwards, J. Serrano, M. Snuderl, A. Stahl, A. Tveito, E. W. Miller and K. E. Healy

Metabolically driven maturation of human-induced-pluripotent-stem-cell-derived cardiac microtissues on microfluidic chips

Nature Biomedical Engineering

X. Shen, J. van den Brink, A. Bergan-Dahl, T. R. Kolstad, E. S. Norden, Y. Hou, M. Laasmaa, Y. Aguilar-Sanchez, A. P. Quick, E. K. S. Espe, I. Sjaastad, X. H. Wehrens, A. G. Edwards, C. Soeller and W. E. Louch

Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes

eLife

K. H. Jæger, A. G. Edwards, W. R. Giles and A. Tveito

Arrhythmogenic influence of mutations in a myocyte‑based computational model of the pulmonary vein sleeve

Nature Scientific Reports

A. G. Edwards, H. Mørk, M. K. Stokke, D. B. Lipsett, I. Sjaastad, S. Richard, O. M. Sejersted and W. E. Louch

Sarcoplasmic Reticulum Calcium Release Is Required for Arrhythmogenesis in the MouseData_Sheet_1.pdf

Frontiers in Physiology

A. F. Iseppe, H. Ni, S. Zhu, X. Zhang, R. Coppini, P. Yang, U. Srivatsa, C. E. Clancy, A. G. Edwards, S. Morotti and E. Grandi

Sex‐Specific Classification of Drug‐Induced Torsade de Pointes Susceptibility Using Cardiac Simulations and Machine Learning

Clinical Pharmacology & Therapeutics

K. H. Jæger, A. G. Edwards, W. R. Giles and A. Tveito

From Millimeters to Micrometers; Re-introducing Myocytes in Models of Cardiac Electrophysiology

Frontiers in Physiology

K. H. Jæger, A. G. Edwards, W. R. Giles and A. Tveito

A computational method for identifying an optimal combination of existing drugs to repair the action potentials of SQT1 ventricular myocytes

PLoS Computational Biology

B. Charrez, V. Charwat, B. Siemons, H. Finsberg, E. Miller, A. G. Edwards and K. E. Healy

In vitro safety “clinical trial” of the cardiac liability of drug polytherapy

Clinical and Translational Science

B. Charrez, V. Charwat, B. Siemons, I. Goswami, C. Sakolish, Y. Luo, H. Finsberg, A. G. Edwards, E. Miller, I. Rusyn and K. Healy

Heart Muscle Microphysiological System for Cardiac Liability Prediction of Repurposed COVID-19 Therapeutics

Frontiers in Pharmacology

A. G. Edwards, J. van den Brink and A. D. McCulloch

Calcium Signaling in Cardiomyocyte Models With Realistic Geometries

Zipes and Jalife's Cardiac Electrophysiology: From Cell to Bedside

B. Charrez, V. Charwat, B. Siemons, H. Finsberg, E. Miller, A. G. Edwards and K. E. Healy

In Vitro Safety “Clinical Trial” of the Cardiac Liability of Hydroxychloroquine and Azithromycin as COVID19 Polytherapy

Clinical Pharmacology & Therapeutics

T. Mäki-Marttunen, N. Iannella, A. G. Edwards, G. T. Einevoll and K. T. Blackwell

A unified computational model for cortical post-synaptic plasticity

eLife

V. Timmermann, A. T. Quinn, J. Sundnes, S. Wall, A. D. McCulloch and A. G. Edwards

A computational study on integrated mechanisms of mechano-electric feedback in ischemic arrhythmogenesis

SAGE

X. Shen, T. R. Kolstad, J. van den Brink, M. Frisk, Y. Hou, E. Norden, A. G. Edwards, I. Sjaastad, C. Soeller and W. E. Louch

3D Dstorm Imaging Reveals Camkii-Dependent Dispersal of Ryanodine Receptor Clusters in Failing Rat Cardiomyocytes

Biophysical Journal

V. Timmermann, A. G. Edwards, S. Wall, J. Sundnes and A. D. McCulloch

Arrhythmogenic current generation by myofilament-triggered Ca2+ release and sarcomere heterogeneity

Biophysical Journal

T. Mäki-Marttunen, T. Kaufmann, T. Elvs\aashagen, A. Devor, S. Djurovic, L. T. Westlye, M. Linne, M. Rietschel, D. Schubert, S. Borgwardt, M. Efrim-Budisteanu, F. Bettella, G. Halnes, E. Hagen, S. Næss, T. Ness, T. Moberget, C. Metzner, A. G. Edwards, M. Fyhn, A. M. Dale, G. T. Einevoll and O. A. Andreassen

Biophysical Psychiatry—How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders

Frontiers in psychiatry

K. H. Jæger, A. G. Edwards, A. D. McCulloch and A. Tveito

Properties of cardiac conduction in a cell-based computational model

PLoS Computational Biology

X. Shen, J. van den Brink, Y. Hou, D. Colli, C. Le, T. R. Kolstad, N. MacQuaide, C. R. Carlson, P. M. Kekenes-Huskey, A. G. Edwards, C. Soeller and W. E. Louch

3D dSTORM imaging reveals novel detail of ryanodine receptor localization in rat cardiac myocytes

The Journal of Physiology

V. Timmermann, J. Sundnes, S. Wall, A. D. McCulloch and A. G. Edwards

A one-dimensional computational study of mechano-electric feedback and arrhythmogenic current generation

Gordon Research Conference "Cardiac Arrhythmia Mechanisms", Barga, Italy

I. van Herck, B. H. Bentzen, V. Seutin, H. Arevalo, M. Maleckar, N. Marrion and A. G. Edwards

Model development of sk channel gating incorporating calcium sensitivity and drug interaction

Biophysical Journal

T. Mäki-Marttunen, F. Krull, F. Bettella, E. Hagen, S. Næss, T. Ness, T. Moberget, T. Elvs\aashagen, C. Metzner, A. Devor, A. G. Edwards, M. Fyhn, S. Djurovic, A. M. Dale, O. A. Andreassen and G. T. Einevoll

Alterations in Schizophrenia-Associated Genes Can Lead to Increased Power in Delta Oscillations

Cerebral Cortex

N. Huebsch, B. Charrez, B. Siemons, S. C. Boggess, S. Wall, V. Charwat, K. Jaeger, F. L. T. Montiel, N. C. Jeffreys, N. Deveshwar, A. G. Edwards, J. Serrano, M. Snuderl, A. Stahl, A. Tveito, E. W. Miller and K. E. Healy

Metabolically-Driven Maturation of hiPSC-Cell Derived Heart-on-a-Chip

{bioRxiv

T. R. Kolstad, J. van den Brink, N. MacQuaide, P. K. Lunde, M. Frisk, J. M. Aronsen, E. S. Norden, A. Cataliotti, I. Sjaastad, O. M. Sejersted, A. G. Edwards, G. T. Lines and W. E. Louch

Ryanodine Receptor Dispersion Disrupts Ca2+-Release in Failing Cardiac Myocytes

eLife

M. Vagos, I. G. M. van Herck, J. Sundnes, H. Arevalo, A. G. Edwards and J. Koivumäki

Computational Modeling of Electrophysiology and Pharmacotherapy of Atrial Fibrillation: Recent Advances and Future Challenges

Frontiers in Physiology

A. Tveito, K. H. Jæger, N. Huebsch, B. Charrez, A. G. Edwards, S. Wall and K. E. Healy

Inversion and computational maturation of drug response using human stem cell derived cardiomyocytes in microphysiological systems

Nature Scientific Reports

I. G. M. van Herck, B. H. Bentzen, V. Seutin, J. Koivumäki, M. Maleckar, N. Marrion and A. G. Edwards

In silico Model of Gating Kinetics, Temperature Dependence and Calcium Sensitivity of the SK Channel

I. G. M. van Herck, B. H. Bentzen, V. Seutin, H. Arevalo, M. Maleckar, N. Marrion and A. G. Edwards

Model development of SK channel gating incorporating calcium sensitivity and drug interaction

V. Timmermann, J. Sundnes, S. Wall, A. D. McCulloch and A. G. Edwards

A computational study of the contribution of mechano-electric feedback to arrhythmogenic current generation

Berlin, Germany

S. Wall, A. Tveito, K. H. Jæger, A. G. Edwards, K. Healy, N. Huebsch and B. Charrez

In Silico Modeling of Cardiac Microphysiological Systems for Evaluating Drug Side Effects

Heart By Numbers Conference, Berlin, Germany

V. Timmermann, L. A. Dejgaard, K. H. Haugaa, A. G. Edwards, A. D. McCulloch, J. Sundnes and S. Wall

An integrative appraisal of mechano-electric feedback mechanisms in the heart

Progress in biophysics and molecular biology

M. Maleckar, A. G. Edwards, W. E. Louch and G. T. Lines

Studying dyadic structure–function relationships: a review of current modeling approaches and new insights into ca2+ (mis) handling

Clinical Medicine Insights: Cardiology

A. G. Edwards and W. E. Louch

Species-Dependent Mechanisms of Cardiac Arrhythmia: A Cellular Focus

Clinical Medicine Insights: Cardiology

V. Timmermann, L. A. Dejgaard, K. H. Haugaa, A. G. Edwards, J. Sundnes, A. D. McCulloch and S. Wall

An integrative appraisal of mechano-electric feedback mechanisms in the heart

Progress in biophysics and molecular biology

T. Mäki-Marttunen, G. T. Lines, A. G. Edwards, A. Tveito, A. M. Dale, G. T. Einevoll and O. A. Andreassen

Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling

Translational Psychiatry

A. Tveito, K. H. Jæger, G. T. Lines, Ł. Paszkowski, J. Sundnes, A. G. Edwards, T. Mäki-Marttunen, G. Halnes and G. T. Einevoll

An Evaluation of the Accuracy of Classical Models for Computing the Membrane Potential and Extracellular Potential for Neurons

Frontiers in Computational Neuroscience

I. G. M. van Herck, R. S. Vicens, H. Arevalo, J. Koivumäki, B. H. Bentzen and A. G. Edwards

Small conductance calcium activated potassium channel: pharmacology and binding scheme for in silico model

V. Timmermann, S. Wall, J. Sundnes, T. A. Quinn and A. G. Edwards

Integrated Mechanisms of Mechano-Electric Feedback in Ischemic Arrhythmogenesis

V. Timmermann, L. A. Dejgaard, A. D. McCulloch, K. H. Haugaa, A. G. Edwards and S. Wall

Role of Electromechanical Feedback in Stretch Induced Arrhythmias : From Single Myocyte to Multicellular Level

V. Timmermann, A. G. Edwards, J. Sundnes, A. D. McCulloch, S. Wall and T. A. Quinn

Integrated Mechanisms of Mechano-Electric feedback in Ischemic Arrhythmogenesis

Bergen, Norway

A. Tveito, G. T. Lines, A. G. Edwards and A. D. McCulloch

Computing rates of Markov models of voltage-gated ion channels by inverting partial differential equations governing the probability density functions of the conducting and non-conducting states

Mathematical Biosciences

V. Timmermann, A. G. Edwards, J. Sundnes, A. D. McCulloch and S. Wall

Role of Electromechanical Feedback in Mitral Valve Prolapse Arrhythmia