|Authors||B. L. de Oliveira, S. Wall and J. Sundnes|
|Title||Multiple Mechanoelectrical Feedback Mechanisms Affect Conduction Velocity|
|Year of Publication||2012|
|Publisher||Cardiac Physiome Workshop|
Mechanical deformation is know to have an influence on the velocity of the electrical conduction in cardiac tissue. Although this is an acknowledged phenomenon, there is still controversy with respect to the underlying biophysical mechanisms. Several experimental and computational studies have investigated this and a wide variety of different strain-conduction velocity relationships have been reported. In short, there are increasing, decreasing, constant and biphasic relationships reported. The objective of this study is to develop a computational model that includes multiple mechanoelectrical feedback mechanisms and is capable of reproducing different strain-conduction velocity relationships reported on experiments.