Authors | M. Vagos, J. Heijman, H. Arevalo, M. Maleckar, B. L. de Oliveira, U. Schotten and J. Sundnes |
Title | A Novel Computational Model of the Rabbit Atrial Myocyte Offers Insight into Calcium Wave Propagation Failure |
Afilliation | Scientific Computing |
Project(s) | AFib-TrainNet: EU Training Network on Novel Targets and Methods in Atrial Fibrillation |
Status | Published |
Publication Type | Poster |
Year of Publication | 2018 |
Secondary Title | Biophysical Journal |
Date Published | Jan-02-2018 |
Place Published | Cambridge, USA |
ISSN Number | 00063495 |
Abstract | Atrial cardiomyocytes have a less well-developed T-tubule system than ventricular cells, resulting in intracellular calcium waves propagating from the membrane to the center via centripetal calcium diffusion. Failure of centripetal calcium-wave propagation (‘calcium silencing’) has been observed in a rabbit model of rapid atrial pacing and in patients with atrial fibrillation, but the underlying mechanisms remain incompletely understood. The goal of this study was to develop a novel computational model of the rabbit atrial cardiomyocyte that incorporates detailed compartmentalization of intracellular calcium dynamics, which can be used to investigate the mechanisms underpinning calcium silencing. |
URL | https://linkinghub.elsevier.com/retrieve/pii/S0006349517319124https://api.elsevier.com/content/article/PII:S0006349517319124?httpAccept=text/xmlhttps://api.elsevier.com/content/article/PII:S0006349517319124?httpAccept=text/plain |
DOI | 10.1016/j.bpj.2017.11.680 |
Citation Key | 26368 |