|Authors||M. R. Vagos, J. Heijman, H. Arevalo, M. M. Maleckar, B. L. de Oliveira, U. Schotten and J. Sundnes|
|Title||A Novel Computational Model of the Rabbit Atrial Myocyte Offers Insight into Calcium Wave Propagation Failure|
|Project(s)||AFib-TrainNet: EU Training Network on Novel Targets and Methods in Atrial Fibrillation|
|Year of Publication||2018|
|Secondary Title||Biophysical Journal|
|Place Published||Cambridge, USA|
Atrial cardiomyocytes have a less well-developed T-tubule system than ventricular cells, resulting in intracellular calcium waves propagating from the membrane to the center via centripetal calcium diffusion. Failure of centripetal calcium-wave propagation (‘calcium silencing’) has been observed in a rabbit model of rapid atrial pacing and in patients with atrial fibrillation, but the underlying mechanisms remain incompletely understood. The goal of this study was to develop a novel computational model of the rabbit atrial cardiomyocyte that incorporates detailed compartmentalization of intracellular calcium dynamics, which can be used to investigate the mechanisms underpinning calcium silencing.