AuthorsA. K. Diem and K. Valen-Sendstad
TitlePorous modelling of cardiac perfusion to optimise targeted drug delivery
AfilliationScientific Computing
Project(s)CUPIDO: Cardio Ultraefficient nanoParticles for Inhalation of Drug prOducts
StatusPublished
Publication TypePoster
Year of Publication2019
Date Published09/2019
Place PublishedComputing in Cardiology
Abstract

Delivery of therapy-loaded nanoparticles (NP) via inhalation is an innovative technology shown to successfully reduce heart failure in mice, improving the efficiency of drug delivery, and reducing adverse side effects. However, how exactly therapeutic NP are distributed and absorbed by heart tissue remains poorly understood, and accelerating this technology to humans is a major challenge. To overcome this problem we developed an open-source finite element model of myocardial perfusion based on porous media, where perfused tissue is treated as a sponge-like continuum material, driven by a continuum model of cardiac contraction to simulate perfusion patterns. We use our novel particle-tracking based method that remains numerically stable under high Peclet number flow to study NP distribution.

Citation Key26552

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