Authors | A. K. Diem and K. Valen-Sendstad |
Title | Time-Lapsing Perfusion: Proof of Concept of a Novel Method to Study Drug Delivery in Whole Organs |
Afilliation | Scientific Computing |
Project(s) | CUPIDO: Cardio Ultraefficient nanoParticles for Inhalation of Drug prOducts |
Status | Published |
Publication Type | Journal Article |
Year of Publication | 2019 |
Journal | Biophysical Journal |
Volume | 117 |
Issue | 12 |
Pagination | 2316-2323 |
Publisher | Cell Press |
Abstract | Perfusion is one of the most important processes maintaining organ health. From a computational perspective, however, perfusion is amongst the least studied physiological processes of the heart. The recent development of novel nanoparticle-based targeted cardiac therapy calls for novel simulation methods that can provide insights into the distribution patterns of therapeutic agents within the heart tissue. Additionally, resolving the distribution patterns of perfusion is crucial for gaining a full understanding of the long-term impacts of cardiovascular diseases that can lead to adverse remodelling, such as myocardial ischemia and heart failure. In this study we have developed and used a novel particle tracking-based method to simulate the perfusion-mediated distribution of nanoparticles or other solutes. To model blood flow through perfused tissue we follow the approach of others and treat the tissue as a porous medium in a continuum model. Classically, solutes are modelled |
Citation Key | 26491 |